Abstract
Aminoglycosides are derivatives of naturally occurring organisms, and several aminoglycosides have been introduced for clinical use since the discovery of streptomycin in 1947. Amikacin, gentamicin, kanamycin, netilmicin, neomycin, streptomycin, paromomycin, and tobramycin are currently approved by the FDA for use in the United States. Among these, amikacin, gentamicin, and tobramycin are most frequently used. Because of the availability of less toxic agents, aminoglycosides have been used less often in recent years. Plazomicin is the newest addition to the list of aminoglycosides approved by the FDA.
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Nicolau, D., Quintiliani, R., & Nightingale, C. H. (1992). Once-daily aminoglycosides. Conn Med, 56(10), 561–563.
Nicolau, D. P., Freeman, C. D., Belliveau, P. P., Nightingale, C. H., Ross, J. W., & Quintiliani, R. (1995). Experience with a once-daily aminoglycoside program administered to 2,184 adult patients. Antimicrob Agents Chemother, 39(3), 650–655.
Shaeer KM, Zmarlicka MT, Chahine EB, Piccicacco N, Cho JC. (2019). Plazomicin: a next generation aminoglycoside. Pharmacotherapy, 39(1):77–93.
Siber, G. R., Echeverria, P., Smith, A. L., Paisley, J. W., & Smith, D. H. (1975). Pharmacokinetics of gentamicin in children and adults. J Infect Dis, 132(6), 637–651.
Zaske, D. E., Cipolle, R. J., Rotschafer, J. C., Solem, L. D., Mosier, N. R., & Strate, R. G. (1982). Gentamicin pharmacokinetics in 1,640 patients: method for control of serum concentrations. Antimicrob Agents Chemother, 21(3), 407–411.
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Finberg, R.W., Guharoy, R. (2021). Aminoglycosides. In: Clinical Use of Anti-infective Agents. Springer, Cham. https://doi.org/10.1007/978-3-030-67459-5_10
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DOI: https://doi.org/10.1007/978-3-030-67459-5_10
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