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Antiproliferative, antimigratory, and apoptotic effects of diffractaic and vulpinic acids as thioredoxin reductase 1 inhibitors on cervical cancer
Cervical cancer is among the most frequently observed cancer types in females. New therapeutic targets are needed because of the side impacts of...
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Thioredoxin-1 Protects Neurons Through Inhibiting NLRP1-Mediated Neuronal Pyroptosis in Models of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease all over the world. In the last decade, accumulating proofs have evidenced that...
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Diffractaic acid exerts anti-cancer effects on hepatocellular carcinoma HepG2 cells by inducing apoptosis and suppressing migration through targeting thioredoxin reductase 1
Hepatocellular carcinoma (HCC) represents one of the most common malignant tumors worldwide. Due to the limited number of available drugs and their...
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Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells
BackgroundTargeting glycolysis in cancer is an attractive approach for therapeutic intervention. 2-Deoxyglucose (2DG) is a synthetic glucose analog...
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The blood level of thioredoxin 1 as a supporting biomarker in the detection of breast cancer
BackgroundThere is a long-time unmet need for a means to detect breast cancer (BC) using blood. Although mammography is accepted as the gold standard...
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Involvement of Peroxiredoxin-3, Thioredoxin-2, and Protein Deglycase-1 in Cypermethrin-Induced Parkinsonism
Owing to its lipophilic nature, cypermethrin makes entry into the brain through the blood–brain barrier and causes severe damage to the nigrostriatal...
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Overexpression of thioredoxin reductase 1 can reduce DNA damage, mitochondrial autophagy and endoplasmic reticulum stress in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Several...
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Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response
Ischemia and reperfusion events, such as myocardial infarction (MI), are reported to induce remote organ damage severely compromising patient...
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Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4
Parkinson’s disease (PD), a common neurodegenerative disease, is typically associated with the loss of dopaminergic neuron in the substantia nigra...
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Expression of thioredoxin 1 and peroxiredoxins in squamous cervical carcinoma and its predictive role in NACT
BackgroundThis study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma...
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The effect of SP/NK1R on expression and activity of glutaredoxin and thioredoxin proteins in prostate cancer cells
Substance P (SP), an important neuropeptide, has a crucial role in the progression of several cancers, including prostate cancer, through interacting...
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Modulation of the Nrf-2 and HO-1 signalling axis is associated with Betaine’s abatement of fluoride-induced hepatorenal toxicities in rats
Sodium fluoride (NaF) ingestion has several detrimental effects in humans and rodents. NaF mechanisms of toxicity include perturbation of...
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Effect of Changes in the Redox Status on Biofilm Formation in Escherichia coli
Changes in the redox balance in the medium and in Escherichia coli cells significantly affect the ability of bacteria to form biofilms. An increase...
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Epigallocatechin Gallate Alleviates Down-Regulation of Thioredoxin in Ischemic Brain Damage and Glutamate-Exposed Neuron
Epigallocatechin gallate (EGCG) is one of polyphenol that is abundant in green tea. It has anti-oxidative activity and exerts neuroprotective effects...
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Understanding the Functions of Longevity Genes in Drosophila
The fruit fly, Drosophila melanogaster, has been an excellent model organism to study aging and longevity. A number of genes affecting longevity have...
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Comparative proteomic analysis of wall-forming bodies and oocyst wall reveals the molecular basis underlying oocyst wall formation in Eimeria necatrix
BackgroundThe durable oocyst wall formed from the contents of wall-forming bodies (WFBs) protects Eimeria parasites from harsh conditions and...
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The stress-responsive protein REDD1 and its pathophysiological functions
Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including...
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SBP1 promotes tumorigenesis of thyroid cancer through TXN/NIS pathway
BackgroundAs the tissue with the highest selenium content in the body, the occurrence and development of thyroid cancer are closely related to...
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Redox regulation of the immune response
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role...
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Serological evaluation of the schistosome’s secretory enzyme phytochelatin synthase and phosphoglycerate mutase for the detection of human Schistosoma japonicum infection
Secretory enzymes from Schistosoma japonicum are promising candidate antigens in the diagnosis of schistosomiasis. Our previous studies have proven...
