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Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
As a potential vectored vaccine, Newcastle disease virus (NDV) has been subject to various studies for vaccine development, while relatively little...
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Development of an indirect ELISA to specifically detect antibodies against African swine fever virus: bioinformatics approaches
BackgroundAfrican swine fever (ASF), characterized by acute, severe, and fast-spreading, is a highly lethal swine infectious disease caused by the...
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High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing
Of the 12 full-length feline leukocyte antigen class I (FLAI) loci, 3 are presumed to be classical: FLAI-E , FLAI-H , and FLAI-K . As diversity is a...
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Differential blood leukocyte populations based on individual variances and age
Blood was collected from the New York State Department of Health (NYSDOH) employees to assess variances in leukocyte numbers in January, May, and...
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African Swine Fever Virus
African swine fever virus introduction to naïve swine population leads to high mortality and losses among susceptible animals. ASF epidemic in Russia...
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Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
BackgroundInfluenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health. Vaccination of pigs is the most...
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Classical Swine Fever Virus
Classical swine fever virus (CSFV), belonging to the genus Pestivirus of the family Flaviviridae and species Pestivirus C, is the aetiological agent...
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Development of transplantable B-cell lymphomas in the MHC-defined miniature swine model
BackgroundEstablishment of transplantable tumors in clinically relevant large animals allows translational studies of novel cancer therapeutics.
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Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens
Xenotransplantation of pig organs into people may help alleviate the critical shortage of donors which faces organ transplantation. Unfortunately,...
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A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva
BackgroundThe argasid tick Ornithodoros erraticus is the main vector of tick-borne human relapsing fever (TBRF) and African swine fever (ASF) in the...
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Sleep Disturbances and COVID-19 Vaccines
Sleep and the immune system have a bidirectional relationship, as sleep can strengthen the immune system to achieve balanced and effective immune...
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Cell Culture System for Porcine Virus Isolation and Propagation
Cell culture is an integral part of virology as the viruses are the obligate intracellular parasites that require replication inside a living cell to...
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Roles of Glycans and Non-glycans on the Epithelium and in the Immune System in H1–H18 Influenza A Virus Infections
The large variation of influenza A viruses (IAVs) in various susceptible hosts and their rapid evolution, which allows host/tissue switching, host...
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The fate of adipose tissue and adipose-derived stem cells in allograft
Utilizing adipose tissue and adipose-derived stem cells (ADSCs) turned into a promising field of allograft in recent years. The therapeutic potential...
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Cytokines and Chemokines in Tumor Growth and Progression
The significance of cytokines as signaling molecules, which has long been acknowledged, is expanding as a result of their connection to malignancies...
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mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop...
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising...
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New Approaches to Evaluate the Cytotoxic Potential of Leishmanicidal Drugs Using Human Peripheral Blood
Parasite resistance and few therapeutic options are challenges that need to be overcome for effective treatment of leishmaniasis. In the drug...
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Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. Although ex vivo lung...
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Animal Models of Behçet’s Disease
Behçet’s disease (BD) is an inflammatory multisystem disorder with clinical characteristics of uveitis, recurrent oral aphthae, vasculitis, and...