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Production of Stem Cell Antigen 1 Sca-1/Ly-6A/E by Freshly Isolated NK Cells Cultured with Relevant Cytokines
Activated NK cells in appropriate conditions are known to express stem cell antigen 1 (Sca-1/Ly-6A/E). To investigate its production, NK cells...
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Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
CD4 + T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8 + T lymphocytes. In...
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PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape
Adaptive immunity relies on specialized effector functions elicited by lymphocytes, yet how antigen recognition activates appropriate effector...
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Glucocorticoid signaling and regulatory T cells cooperate to maintain the hair-follicle stem-cell niche
Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (T reg...
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Differential activation of Ca2+ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration
Stem cells have indefinite self-renewable capability; however, factors that modulate their pluripotency/function are not fully identified. Here we...
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Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice
One goal of regenerative medicine is to rejuvenate tissues and extend lifespan by restoring the function of endogenous aged stem cells. However,...
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Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors
Regeneration of functional B lymphopoiesis from pluripotent stem cells (PSCs) is challenging, and reliable methods have not been developed. Here, we...
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Chronic LCMV infection regulates the effector T cell response by inducing the generation of less immunogenic dendritic cells
Chronic viral infection impairs systemic immunity in the host; however, the mechanism underlying the dysfunction of immune cells in chronic viral...
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In Vivo Clonal Analysis of Aged Hematopoietic Stem Cells: Single-Cell Transplantation
Hematopoietic stem cells (HSCs) display heterogeneity in their characteristic features of undergoing self-renewal and multipotency within the blood...
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Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy
Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of hematopoietic stem cells (HSCs). The current standard of care for patients...
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Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells
While targeting CD19+ hematologic malignancies with CAR T cell therapy using single chain variable fragments (scFv) has been highly successful, novel...
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A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Following acute injury, stromal cells promote tissue regeneration by a diversity of mechanisms. Time-resolved single-cell RNA sequencing of muscle...
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Purification of Bone Marrow Precursors to T Cells and ILCs
T cells and innate lymphoid cells (ILCs) share expression of many key transcription factors during development and at mature stage, resulting in...
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Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations
Mesenchymal stem/stromal cells (MSCs) represent a heterogeneous cell population distributed throughout various tissues, demonstrating remarkable...
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GRK2 regulates group 2 innate lymphoid cell mobilization in sepsis
BackgroundSepsis induces group 2 innate lymphoid cell (ILC2) expansion in the lung. However, the origin of these lung-recruited ILC2 and the...
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Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology
Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we investigated the impact of age-related changes in the immune system...
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Genomic and functional impact of Trp53 inactivation in JAK2V617F myeloproliferative neoplasms
Classical myeloproliferative neoplasms (MPNs) are characterized by the proliferation of myeloid cells and the risk of transformation into...
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Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet...
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Bone marrow stem cells accelerate lung maturation and prevent the LPS-induced delay of morphological and functional fetal lung development in the presence of ErbB4
ErbB4 is a regulator in lung development and disease. Prenatal infection is an important risk factor for the delay of morphologic lung development,...
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The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage
Innate lymphoid cells (ILCs) play important functions in immunity and tissue homeostasis, but their development is poorly understood. Through the use...
