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STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer
BackgroundThe primary cilia (PC) is a microtubule-based and nonmotile organelle which protrudes from the surface of almost all mammalian cells. At...
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ncRNAs-mediated overexpression of STIL predict unfavorable prognosis and correlated with the efficacy of immunotherapy of hepatocellular carcinoma
BackgroundSTIL centriolar assembly protein (STIL) is a cytoplasmic protein implicated in cellular growth and proliferation as well as chromosomal...
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A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
BackgroundMetastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial–mesenchymal...
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The biological function and clinical significance of STIL in osteosarcoma
BackgroundSCL/TAL1 interrupting locus (STIL) is associated with the progression of several tumors; however, the biological role of STIL in...
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Deep learning model improves tumor-infiltrating lymphocyte evaluation and therapeutic response prediction in breast cancer
Tumor-infiltrating lymphocytes (TILs) have been recognized as key players in the tumor microenvironment of breast cancer, but substantial...
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Impact of stromal tumor-infiltrating lymphocytes (sTILs) on response to neoadjuvant chemotherapy in triple-negative early breast cancer in the WSG-ADAPT TN trial
BackgroundHigher density of stromal tumor-infiltrating lymphocytes (sTILs) at baseline has been associated with increased rates of pathological...
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Integrated analysis of transcriptome and genome variations in pediatric T cell acute lymphoblastic leukemia: data from north Indian tertiary care center
IntroductionT-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with poor prognosis and inferior outcome. Although...
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Multiplex immunofluorescence to measure dynamic changes in tumor-infiltrating lymphocytes and PD-L1 in early-stage breast cancer
BackgroundThe H&E stromal tumor-infiltrating lymphocyte (sTIL) score and programmed death ligand 1 (PD-L1) SP142 immunohistochemistry assay are...
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Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer
Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast...
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Neoadjuvant durvalumab plus weekly nab-paclitaxel and dose-dense doxorubicin/cyclophosphamide in triple-negative breast cancer
The goal of this Phase I/II trial is to assess the safety and efficacy of administering durvalumab concurrent with weekly nab-paclitaxel and...
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Hypodiploidy in a pediatric patient of T-cell acute lymphoblastic leukemia: a case report
BackgroundT-cell acute lymphoblastic leukemia is a subtype of acute lymphoblastic leukemia, one of the most common childhood neoplasms. Hypodiploidy...
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Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer
BackgroundBreast cancer (BC) immune infiltrates play a critical role in tumor progression and response to treatment. Besides stromal tumor...
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Kreativität: Generative Künstliche Intelligenz
Kreativität bedeutet, etwas zu erschaffen, was neu und nützlich ist. Bending, Blending und Breaking sind drei verschiedene Strategien, um Kreativität...
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Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression
The critical importance of circular RNAs (circRNAs) in human cancers, including cervical cancer (CC), has been discovered in recent years. However,...
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The prognostic value of tumour-infiltrating lymphocytes, programmed cell death protein-1 and programmed cell death ligand-1 in Stage I–III triple-negative breast cancer
BackgroundTumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however,...
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Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases
BackgroundMetaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy....
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Deep learning-based predictive biomarker of pathological complete response to neoadjuvant chemotherapy from histological images in breast cancer
BackgroundPathological complete response (pCR) is considered a surrogate endpoint for favorable survival in breast cancer patients treated with...
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Whole‐exome sequencing of a Saudi epilepsy cohort reveals association signals in known and potentially novel loci
BackgroundEpilepsy, a serious chronic neurological condition effecting up to 100 million people globally, has clear genetic underpinnings including...
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Prodromal Parkinson disease signs are predicted by a whole-blood inflammatory transcriptional signature in young Pink1−/− rats
BackgroundParkinson disease (PD) is the fastest growing neurodegenerative disease. The molecular pathology of PD in the prodromal phase is poorly...
