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Photochemistry of nitric oxide and S-nitrosothiols in human skin
Nitric oxide (NO) is related to a wide range of physiological processes such as vasodilation, macrophages cytotoxicity and wound healing. The human...
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DNIC is a Structure Providing Specificity of Physiological Effects of NO
Metabolism of nitric oxide (NO) donors: dinitrosyl iron complexes (DNIC), nitrosothiols (RSNO), and nitroprusside was studied on a chick embryo...
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The effects of ecdysterone and enalapril on nitric oxide synthesis and the markers of oxidative stress in streptozotocin-induced diabetes in rats: a comparative study
Cardiovascular functions in diabetes greatly depend on constitutive NOS (cNOS) activity. A comparative study of the effects of a steroid hormone...
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Synthesis and Metabolism of Nitric Oxide (NO) in Chicken Embryos and in the Blood of Adult Chicken
In chicken embryos, nitric oxide (NO) is accumulated in the pool of NO donors: S-nitrosothiols, nitrosyl-iron complexes, high-molecular-weight...
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Nitric Oxide as a Diagnostic and Therapeutic Tool in Respiratory Diseases
Nitric oxide (NO) is a gasotransmitter that plays a vital role in diverse biological processes. NO is a fundamental component in regulating...
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Modification of Biochemical Properties of Nitrosothiol by Fe3+ Cation: A Presumable Physiological Role
In the presence of Fe 3+ cation, S - nitrosoglutathione (GSNO) loses the potency to inhibit catalase in the system containing hemoglobin (an NO trap)...
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Diligustilide releases H2S and stabilizes S-nitrosothiols in ethanol-induced lesions on rat gastric mucosa
(Z,Z’)-Diligustilide (DLG) or levistolide A is a dimeric phthalide isolated from Ligusticum porteri (Osha), the roots of which are used in the...
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Methods to Detect Nitric Oxide and Reactive Nitrogen Species in Biological Sample
Oxidative stress has been implicated in various human diseases, including cancer, mainly through the generation of reactive nitrogen species (RNS),...
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Role of Inflammatory Cytokines in Pathophysiology of Psoriasis
Purpose of ReviewPsoriasis is a widespread inflammatory skin disease affecting approximately 2% of the world population and characterized by scaly...
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Role of Nitric Oxide Synthases in Doxorubicin-Induced Cardiomyopathy
Since the discovery of Doxorubicin (Dox), its safe use is under intense discussion due to its cardiotoxic side effects manifested in patients at...
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Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter
We studied the effect of nitric oxide (NO) on the functioning of P-glycoprotein transporter (Pgp) in Caco-2 cells. NO donor S-nitrosoglutathione...
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Putative Role of Ligands of DNIC in the Physiological Action of the Complex
In a relatively isolated system of avian embryo, the metabolism of NO, a component of the dinitrosyl iron complexes (DNIC), the main NO donor in most...
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Translating Nitric Oxide Research to Therapeutics: A Critical Appraisal
Nitric oxide (NO) is a signaling molecule with an extensive range of functions in both health and disease. Initially proposed as a regulator of...
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Nitric Oxide-cGMP-PKG Signaling in the Cardioprotective Effects of Phosphodiesterase 5 Inhibitors
Phosphodiesterase 5 (PDE5) is an enzyme that catalyzes the degradation of cGMP to its inactive form, 5′-GMP. The inhibition of PDE5 leads to the...
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Ruthenium Nitrosyl Complexes: Photoinduced Delivery of NO to Different Biological Targets
Nitric oxide (NO) molecule participates in various biological events such as vasodilation, neurotransmission, antioxidant, and immune responses. In...
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Short-term cocoa bioflavanol supplementation does not improve cold-induced vasodilation in young healthy adults
PurposeCold-induced vasodilation (CIVD) is an oscillatory rise in blood flow to glabrous skin that occurs in cold-exposed extremities. Dietary...
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Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke
Ischemic stroke is a major global health issue and characterized by acute vascular dysfunction and subsequent neuroinflammation. However, the...
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Nitric Oxide, Vasoactive Peptides, and Purines
This chapter explains in detail, the role of nitric oxide pathway and its players, in health and disease. These players may be endogenous (activators...