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1. Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

   Neurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic...

   Anne Rombaut, Danica Jovancevic, ... Pete A. Williams in Acta Neuropathologica Communications

   Article Open access 21 May 2024
   

2. Gene Gun DiOlistic Labelling of Retinal Ganglion Cells

   Gene gun DiOlistic labelling enables the detailed visualization of retinal ganglion cells (RGCs) dendritic structure. Since the level of labelling is...

   Gloria Cimaglia, Ryan J. Bevan, ... James E. Morgan in Retinal Ganglion Cells

   Protocol 2023
   

3. AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes

   Recombinant adeno-associated virus (AAV)-2 has significant potential as a delivery vehicle of therapeutic genes to retinal ganglion cells (RGCs),...

   Brahim Chaqour, Thu T. Duong, ... Ahmara G. Ross in Gene Therapy

   Article 10 January 2024
   

4. Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

   Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in...

   Alessio Canovai, James R. Tribble, ... Pete A. Williams in Acta Neuropathologica Communications

   Article Open access 08 September 2023
   

5. Methods to Identify Rat and Mouse Retinal Ganglion Cells in Retinal Flat-Mounts

   The identification of distinct retinal ganglion cell (RGC) populations in flat-mounted retinas is key to investigating pathological or...

   Juan A. Miralles de Imperial-Ollero, Beatriz Vidal-Villegas, ... Francisco J. Valiente-Soriano in Retinal Ganglion Cells

   Protocol 2023
   

6. CREG Protects Retinal Ganglion Cells loss and Retinal Function Impairment Against ischemia-reperfusion Injury in mice via Akt Signaling Pathway

   Purpose

   The irreversible death of retinal ganglion cells (RGCs) plays an important role in the pathogenesis of glaucoma. Cellular repressor of...

   Siyu Zeng, Lei Du, ... Yiqiao **ng in Molecular Neurobiology

   Article 04 July 2023
   

7. Cerebrospinal Fluid Pressure Reduction Induces Glia-Mediated Retinal Inflammation and Leads to Retinal Ganglion Cell Injury in Rats

   Low intracranial pressure (LICP)–induced translaminar cribrosa pressure difference (TLCPD) elevation has been proven as a risk factor in glaucomatous...

   Ying Cheng, Danting Lin, ... Ningli Wang in Molecular Neurobiology

   Article 22 June 2023
   

8. Confocal Scanning Laser Ophthalmoscopy to Image Retinal Ganglion Cells in Real-Time

   Real-time imaging of retinal ganglion cells (RGCs) provides an opportunity for detailed investigation of retinal development, disease mechanisms, and...

   Lili Hao, Yuan Liu, ... Richard K. Lee in Retinal Ganglion Cells

   Protocol 2023
   

9. Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models

   Background

   Retinal ischemia/reperfusion (RIR) is implicated in various forms of optic neuropathies, yet effective treatments are lacking. RIR leads to...

   Jiawen Wu, Daowei zhang, ... Shenghai Zhang in Journal of Translational Medicine

   Article Open access 13 May 2024
   

10. Differentiation of Human Embryonic/Induced-Pluripotent Stem Cells to Retinal Ganglion Cells

    The generation of retinal ganglion cells (RGCs) differentiated from human embryonic stem cell (hESC) or induced-pluripotent stem cells (iPSC) could...

    Maryam Esmaeili, Ben Mead in Retinal Ganglion Cells

    Protocol 2023
    

11. Generation and Isolation of Retinal Ganglion Cells and Photoreceptors from Human iPSC-Derived Retinal Organoids by Magnetic-Activated Cell Sorting

    Inherited visual disorders, major cause of visual impairment, can be subdivided into inherited retinal dystrophies (iRD), due to the progressive loss...

    G. Orieux, O. Rabesandratana, ... O. Goureau in Brain Organoid Research

    Protocol 2023
    

12. Isolation and Culture of Primary Retinal Ganglion Cells from Rodent Retina

    Primary retinal ganglion cell (RGC) cultures are widely used for evaluating the neuroprotective and neurogenic effects of candidate compounds. The...

    Esmahan Durmaz, Matyas Kutnyanszky, Ben Mead in Retinal Ganglion Cells

    Protocol 2023
    

13. Intravitreal Injection of AAV for the Transduction of Mouse Retinal Ganglion Cells

    The injection of therapies into the eye is common practice, both clinically and pre-clinically. The most straightforward delivery route is via an...

    Bart Nieuwenhuis, Andrew Osborne in Retinal Ganglion Cells

    Protocol 2023
    

14. Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection

    The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading...

    Myung** Kim, Jun Yong Kim, ... Seungsoo Rho in Acta Neuropathologica Communications

    Article Open access 22 April 2024
    

15. NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell Regeneration After Optic Nerve Injury

    Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve, fail to regenerate their axons after injury. The...

    Joanna Mackiewicz, Julia Tomczak, ... Tomasz Boczek in Molecular Neurobiology

    Article Open access 19 April 2024
    

16. Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials

    Glaucoma is a group of diseases characterized by the degeneration of retinal ganglion cells (RGCs) and progressive, irreversible vision loss. High...

    Wen-juan Zhao, Chun-ling Fan, ... Kun **ong in Cellular and Molecular Neurobiology

    Article 20 June 2023
    

17. Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma

    Normal tension glaucoma (NTG) is a progressive neurodegenerative disease in glaucoma families. Typical glaucoma develops because of increased...

    Yuebing Wang, Musukha Mala Brahma, ... Toshio Ohshima in NeuroMolecular Medicine

    Article Open access 15 April 2024
    

18. Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2

    Background

    In addition to rescuing injured retinal ganglion cells (RGCs) by stimulating the intrinsic growth ability of damaged RGCs in various...

    Zi-Yuan Zhang, Zhao-Yang Zuo, ... Guang-Yu Li in Inflammation and Regeneration

    Article Open access 20 June 2023
    

19. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

    Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous...

    Jonathan R. Soucy, Erika A. Aguzzi, ... Thomas V. Johnson in Molecular Neurodegeneration

    Article Open access 21 September 2023
    

20. Progression of Retinal Ganglion Cell and Nerve Fiber Layer Loss in Spinocerebellar Ataxia 3 Patients

    Spectral domain optical coherence tomography (SD-OCT) allows noninvasive measurements of retinal neuron layers. Here, we evaluate the relationship...

    Anna Camós-Carreras, Marc Figueras-Roca, ... Bernardo Sánchez-Dalmau in The Cerebellum

    Article Open access 30 November 2023