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RETRACTED ARTICLE: Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1
Ovarian cancer is a common human malignancy of the female reproductive system. However, chemotherapy has been proven to have limited effectiveness in...
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Retraction Note to: Resibufogenin suppresses tumor growth and inhibits glycolysis in ovarian cancer by modulating PIM1
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s00210-020-02016-8.
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Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis
BackgroundNecroptotic susceptibility is probably an intrinsic weakness of cancer. Here, we report that resibufogenin, a member of bufadienolide...
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Ferroptosis in colorectal cancer: a future target?
Colorectal cancer (CRC) is the third leading cause of cancer deaths worldwide and is characterised by frequently mutated genes, such as APC , TP53 , KRAS ...
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Scaffold-Based Selective ROS Generation as Viable Therapeutic Strategies Against Cancer
Reactive oxygen species (ROS) are by-products of normal cellular metabolism and play a crucial part in cell signaling and common cellular functions....
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Scaffold-Based Selective ROS Generation as Viable Therapeutic Strategies Against Cancer
Reactive oxygen species (ROS) are by-products of normal cellular metabolism and play a crucial part in cell signaling and common cellular functions....
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Metadata analysis of retracted fake papers in Naunyn-Schmiedeberg’s Archives of Pharmacology
An increasing fake paper problem is a cause for concern in the scientific community. These papers look scientific but contain manipulated data or are...
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Characterization of CYP3A5 Selective Inhibitors for Reaction Phenoty** of Drug Candidates
CYP3A is one of the most important classes of enzymes and is involved in the metabolism of over 70% drugs. While several selective CYP3A4 inhibitors...
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The Role of Interleukin-6/GP130 Cytokines in Cancer Cachexia
Cancer cachexia is characterized by the involuntary loss of skeletal muscle with or without adipose tissue loss in the presence of tumor burden. It...
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Ferroptosis: underlying mechanisms and involvement in neurodegenerative diseases
Ferroptosis, a mode of cell death that was recently identified in 2012, is driven by iron-dependent lipid peroxidation and distinct from other...
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How Naunyn-Schmiedeberg’s Archives of Pharmacology deals with fraudulent papers from paper mills
Fraudulent papers from paper mills are a serious threat to the entire scientific community. Naunyn-Schmiedeberg’s Archives of Pharmacology has become...
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The role of necroptosis in cancer biology and therapy
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway...
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Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges
Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths. Surgery,...
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New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin
Aim of the reviewIn the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in...
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The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors
BackgroundCinobufagin is the major bufadienolide of Bufonis venenum (Chansu), which has been traditionally used for the treatment of chronic pain...
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Toad Poison and Drug Discovery
In this chapter, the potential medical-pharmaceutical use of molecules derived from toad skin secretions is discussed. Over the past decades,...
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Digitalis Glycosides
The medical use of cardiac glycosides began in 1785 with the publication of Withering’s monograph on the therapeutic efficacy and toxicity of the...
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Digitalis Glycosides
The medical use of cardiac glycosides began in 1785 with the publication of Withering’s monograph on the therapeutic efficacy and toxicity of the...
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Toad Poison and Drug Discovery
In this chapter, the potential medical-pharmaceutical use of molecules derived from toad skin secretions is discussed. Over the past decades,...