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Evaluating the comprehensive diagnosis efficiency of lung cancer, including measurement of SHOX2 and RASSF1A gene methylation
Methylation of the promoters of SHOX2 and RASSF1A (LungMe®) exhibits promise as a potential molecular biomarker for diagnosing lung cancer. This...
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Association of the SHOX2 and RASSF1A methylation levels with the pathological evolution of early-stage lung adenocarcinoma
Background The methylation of SHOX2 and RASSF1A shows promise as a potential biomarker for the early screening of lung cancer, offering a solution to...
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Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma
BackgroundRAS association domain family protein 1A ( RASSF1A ) promoter hypermethylation is suggested to be linked to hepatocellular carcinoma (HCC),...
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Hypermethylation of Gene Promoters in Blood Leukocytes of Irradiated Individuals—Final Research Results
AbstractHypermethylation of CpG islands in the promoter regions of four genes ( p53 , ATM , SOD3 , ESR1 ) was studied in blood leukocytes of irradiated...
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Investigation of the relationship between CTLA4 and the tumor suppressor RASSF1A and the possible mediating role of STAT4 in a cohort of Egyptian patients infected with hepatitis C virus with and without hepatocellular carcinoma
The Ras association domain family 1 isoform A ( RASSF1A ), cytotoxic T lymphocyte antigen 4 ( CTLA-4 ), and signal transducer and activator of...
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Gene Methylation in Circulating Cell-Free DNA from the Blood Plasma as Prognostic and Predictive Factor in Breast Cancer
AbstractDespite considerable progress in the early-stage diagnostics and treatment of breast cancer (BC), there is a high chance of recurrence. The...
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Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival
BackgroundThere is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by...
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Epigenetic modification and BRAF gene mutation in thyroid carcinoma
Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively increasing incidence rate has been observed in recent years,...
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Early diagnosis of ovarian cancer based on methylation profiles in peripheral blood cell-free DNA: a systematic review
Patients diagnosed with epithelial ovarian cancer (OC) have a 5-year survival rate of 49%. For early-stage disease, the 5-year survival rate is above...
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Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach
BackgroundDNA methylation is an important mechanism in epigenetics, which can change the transcription ability of genes and is closely related to the...
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Contribution of whole genome sequencing in the molecular diagnosis of mosaic partial deletion of the NF1 gene in neurofibromatosis type 1
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease with complete penetrance but highly variable expressivity. In most patients, Next...
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Synergy between the Levels of Methylation of microRNA Gene Sets in Primary Tumors and Metastases of Ovarian Cancer Patients
We studied the correlations between the levels of methylation of a group of 21 microRNA genes in 99 primary tumors and 29 macroscopic peritoneal...
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NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells
BackgroundRASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition...
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The Epigenetic Landscape of Meningiomas
Epigenetic changes have been found to be increasingly important in tumor development and progression. These alterations can be present in tumors such...
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High-risk HPV infection-associated hypermethylated genes in oropharyngeal squamous cell carcinomas
BackgroundHPV-positive oropharyngeal squamous cell carcinomas (OPSCCs) are sensitive to chemo-radiation therapy and have favorable survival outcomes...
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The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer
BackgroundHigh-risk human papillomavirus (HR-HPV) infection is the main cause of cervical cancer, but additional alterations are necessary for its...
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Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis
BackgroundUpregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral...
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Renal Cell Carcinomas
This chapter highlights the molecular mechanisms in some of the many different tumor types that originate in the adult kidney. Renal cell carcinomas...
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Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases
As a key mechanism to maintain cellular homeostasis under stress conditions, autophagy/mitophagy is related to the occurrence of metabolic disorders,...
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Methylation-regulated tumor suppressor gene PDE7B promotes HCC invasion and metastasis through the PI3K/AKT signaling pathway
BackgroundHepatocellular carcinoma (HCC) has a high mortality rate, and the mechanisms underlying tumor development and progression remain unclear....
