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Analyzing immune responses to varied mRNA and protein vaccine sequences
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have...
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Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously...
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Prophylactic Hepatitis E Vaccine
The hepatitis E has been increasingly recognized as an underestimated global disease burden in recent years. Subpopulations with more serious...
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Immunogenicity of the DNA/Protein Combined Vaccine against COVID-19
During the COVID-19 pandemic, the development of prophylactic vaccines, including those based on new platforms, became highly relevant. One such...
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Long-term trial of protection provided by adenovirus-vectored vaccine expressing the PPRV H protein
A recombinant, replication-defective, adenovirus-vectored vaccine expressing the H surface glycoprotein of peste des petits ruminants virus (PPRV)...
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Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents
Respiratory syncytial virus (RSV) is a leading cause of upper and lower respiratory tract infection, especially in children and the elderly. Various...
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Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2
In response to COVID-19 pandemic, we have launched a vaccine development program against SARS-CoV-2. Here we report the safety, tolerability, and...
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Shigella virulence protein VirG is a broadly protective antigen and vaccine candidate
Diarrhea caused by Shigella has been associated with high morbidity and mortality in young children worldwide. There are no licensed vaccines, and...
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Developmental and reproductive toxicity of a recombinant protein subunit COVID-19 vaccine (ZF2001) in rats
ZF2001, a protein subunit vaccine against coronavirus disease 2019 (COVID-19), contains recombinant tandem repeat of dimeric receptor-binding domain...
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Introduction of protein vaccine candidate based on AP65, AP33, and α-actinin proteins against Trichomonas vaginalis parasite: an immunoinformatics design
BackgroundTrichomonas vaginalis is the most common nonviral sexually transmitted disease (STI) worldwide. Vaccination is generally considered to be...
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Vaccine Development Against Melioidosis
Melioidosis in an infectious disease of humans and animals caused by the bacterium Burkholderia pseudomallei. Melioidosis is often considered a...
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Preclinical assessment of an anti-HTLV-1 heterologous DNA/MVA vaccine protocol expressing a multiepitope HBZ protein
BackgroundHuman T-lymphotropic virus 1 (HTLV-1) is associated with the development of several pathologies and chronic infection in humans. The...
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Current Status of Vaccine Development for Monkeypox Virus
Monkeypox virusMonkeypox virus (MPXV) of poxviridae family causes a zoonotic disease called monkeypox (Mpox). MPXV cases have a fatality ratio...
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Immune response induced by recombinant pres2/S-protein and a pres2-S-protein fused with a core 18-27 antigen fragment of hepatitis B virus compared to conventional HBV vaccine
Although comprehensive vaccination is the cornerstone of public health programs to control hepatitis B virus (HBV) infections, 5% of people who...
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Vaccine Development for Human Leishmaniasis
The development of vaccines for human leishmaniasis is one of the most important approaches for effectively controlling and/or eradicating the...
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C-terminal truncation of the hemagglutinin-neuraminidase (HN) protein enhances the virulence and immunogenicity of Newcastle disease virus (NDV) vaccine strain V4
The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) is a multifunctional protein with receptor recognition ability that...
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Bioinformatics analysis of structural protein to approach a vaccine candidate against Vibrio cholerae infection
The bacteria Vibrio cholerae causes cholera, an acute diarrheal infection that can lead to dehydration and even death. Over 100,000 people die each...
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Relevance for mRNA Vaccine Safety
This chapter describes how the above unsubstantiated assumptions underlying mRNA vaccines may impact vaccine safety. Again, the analysis here is done...
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In-silico design and evaluation of an epitope-based serotype-independent promising vaccine candidate for highly cross-reactive regions of pneumococcal surface protein A
BackgroundThe pathogenicity of pneumococcus with high morbidity, mortality, and multi-drug resistance patterns has been increasing. The limited...
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Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is responsible for about more than 722,000 cases in a year, globally....
