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Letrozole Decreased Testosterone-Induced Cell Proliferation and Prolactin Secretion also Increased Apoptosis in MMQ and GH3 Rat Prolactinoma Cell Lines
Aromatase enzyme plays an essential role in estrogen-induced tumorigenesis. It is expressed in the normal pituitary and more significantly in...
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Curcumin Sensitizes Prolactinoma Cells to Bromocriptine by Activating the ERK/EGR1 and Inhibiting the AKT/GSK-3β Signaling Pathway In Vitro and In Vivo
Although bromocriptine (BRC) as first-line drug is recommended for treating patients with prolactinoma, a minority of patients with prolactinoma are...
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The SF3B1R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1
BackgroundRecently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 ( SF3B1 R625H ), but its functional effects and...
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Correlation of serum prolactin with sleep duration, wake-up hour, and phases of the menstrual cycle in healthy adult subjects
Prolactin is affected by several factors: sex, age, BMI, sleep duration, menopausal status, and menstrual cycle phases. However, previous studies on...
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CX3CL1/CX3CR1-signalling in the CD9/S100β/SOX2-positive adult pituitary stem/progenitor cells modulates differentiation into endothelial cells
Approximately 8% of CD9-, S100β- and SOX2-triple positive (CD9/S100β/SOX2-positive) stem/progenitor cells in the anterior lobe of the rat pituitary...
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ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway
ACT001, derived from traditional herbal medicine, is a novel compound with effective anticancer activity in clinical trials. However, little is known...
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The potential link between acromegaly and risk of acute ischemic stroke in patients with pituitary adenoma: a new perspective
Acromegaly is an endocrine disorder due to the excess production of growth hormone (GH) from the anterior pituitary gland after closed epiphyseal...
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Muti-omics integration analysis revealed molecular network alterations in human nonfunctional pituitary neuroendocrine tumors in the framework of 3P medicine
Nonfuctional pituitary neuroendocrine tumor (NF-PitNET) is highly heterogeneous and generally considered a common intracranial tumor. A series of...
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Predictive Value and Immunological Role of the HSPA5 Gene in Cervical Cancer
Cervical cancer (CC) ranks fourth among women’s malignancies worldwide and seriously affects women’s health. HSPA5 is a heat shock protein, also...
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Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors
We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug...
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Challenges in Drug Development for Neurological Disorders
Neurological disorders are the group of pathogen, trauma, or disease induced pathologies that mainly affects our central nervous system, impairing...
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Reverse Pharmacology: A Tool for Drug Discovery from Traditional Medicine
Reverse pharmacology approach reduces the three major bottlenecks of drug discovery. In India this approach is pioneered with the traditional basis...
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Hypothalamic and Pituitary Hormones
Hypothalamus–pituitary–organ axis plays a cardinal role in the maintenance of homeostasis of human body. Hypothalamus and pituitary gland are...
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Histone citrullination: a new target for tumors
As the main protein components of chromatin, histones play central roles in gene regulation as spools of winding DNA. Histones are subject to various...
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Granulocyte-colony stimulating factor (G-CSF): an emerging therapeutic approach for amyotrophic lateral sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by neuronal degeneration and inflammation in the nerves. G-CSF is a...
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DICER1 Syndrome
DICER1 syndrome, known previously as the pleuropulmonary blastoma—familial tumor dysplasia syndrome (OMIM #601200, #138800, #180295), was first...
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Multiple Endocrine Neoplasias and Associated Non-endocrine Conditions
Tumors of hormone-producing tissues are frequent among patients with hereditary cancer syndromes. Lesions in multiple tumor suppressor genes and...