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Exploring Allosteric Inhibitors of Protein Tyrosine Phosphatases Through High-Throughput Screening
High-throughput screening (HTS) using a natural or synthetic chemical or natural product library is a powerful technique for discovering novel...
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The microsporidian polar tube: origin, structure, composition, function, and application
Microsporidia are a class of obligate intracellular parasitic unicellular eukaryotes that infect a variety of hosts, even including humans. Although...
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Role of Non-Receptor-Type Tyrosine Phosphatases in Brain-Related Diseases
The non-receptor protein tyrosine phosphatase is a class of enzymes that catalyze the dephosphorylation of phosphotyrosines in protein molecules....
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A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy
While protein tyrosine kinases (PTKs) play an initiative role in growth factor-mediated cellular processes, protein tyrosine phosphatases (PTPs)...
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Cellular and clinical impact of protein phosphatase enzyme epigenetic silencing in multiple cancer tissues
BackgroundProtein Phosphatase Enzymes (PPE) and protein kinases simultaneously control phosphorylation mechanisms that tightly regulate intracellular...
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Splice-Modulating Antisense Oligonucleotides as Therapeutics for Inherited Metabolic Diseases
The last decade (2013–2023) has seen unprecedented successes in the clinical translation of therapeutic antisense oligonucleotides (ASOs). Eight such...
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Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury
Genotoxic therapy triggers reactive oxygen species (ROS) production and oxidative tissue injury. S-nitrosylation is a selective and reversible...
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Unifying gamma passing rates in patient-specific QA for VMAT lung cancer treatment based on data assimilation
This study aimed to identify systematic errors in measurement-, calculation-, and prediction-based patient-specific quality assurance (PSQA) methods...
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Uncovering the Significance of STEP61 in Alzheimer’s Disease: Structure, Substrates, and Interactome
STEP (STriatal-Enriched Protein Tyrosine Phosphatase) is a brain-specific phosphatase that plays an important role in controlling signaling molecules...
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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
Protein phosphatases act as key regulators of multiple important cellular processes and are attractive therapeutic targets for various diseases....
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The Function and Structure of the Microsporidia Polar Tube
Microsporidia are obligate intracellular pathogens that were initially identified about 160 years ago. Current phylogenetic analysis suggests that...
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Disorders of Tetrahydrobiopterin Metabolism: Experience from South India
BackgroundDisorders of tetrahydrobiopterin metabolism represent a rare group of inherited neurotransmitter disorders that manifests mainly in infancy...
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Acute Hypobaric Hypoxia Exposure Causes Neurobehavioral Impairments in Rats: Role of Brain Catecholamines and Tetrahydrobiopterin Alterations
Hypoxia is a state in which the body or a specific part of the body is deprived of adequate oxygen supply at the tissue level. Sojourners involved in...
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Urinary neopterin and biopterin indicate that inflammation has a role in autism spectrum disorder
Inflammation is thought to be involved in the pathogenesis of autism spectrum disorder (ASD). Pteridine metabolites are biomarkers of inflammation...
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ROS Modulation on Apical Junctional Complex
Reactive oxygen species (ROS) influence tumor microenvironment through the initiation of angiogenesis, cell survival, and metastasis. Metastasis...
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PTPRH promotes the progression of non-small cell lung cancer via glycolysis mediated by the PI3K/AKT/mTOR signaling pathway
BackgroundThe protein tyrosine phosphatase H receptor (PTPRH) is known to regulate the occurrence and development of pancreatic and colorectal...
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JAK/STAT in leukemia: a clinical update
Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of...
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The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications
Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is mostly caused by impairment in the insulin receptor...
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Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has...
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Targeting SHP2 for Cancer Treatment: Advances and Prospects
Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by the PTPN11, is a non-receptor protein tyrosine phosphatase that...