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PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR
The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting...
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
BackgroundParathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when...
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Role of PTHrP in attenuating transient pressure rises and associated afferent nerve activity of the rat bladder
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) as the bladder fills acts as an endogenous DSM relaxant to...
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PTH and PTHrP Actions on Bone
Parathyroid hormone (PTH), PTH-related peptide (PTHrP), PTHR, and their cognate G protein-coupled receptor play defining roles in the regulation of...
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Parathyroid hormone-related peptide and parathyroid hormone-related peptide receptor type 1 in locally advanced laryngeal cancer as prognostic indicators of relapse and survival
BackgroundParathyroid hormone-related peptide (PTHrP) overexpression and poor patient outcome have been reported for many human tumors, but no...
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YTHDF2-mediated FGF14-AS2 decay promotes osteolytic metastasis of breast cancer by enhancing RUNX2 mRNA translation
BackgroundLncRNA FGF14-AS2 is a critical suppressor in breast cancer (BCa) metastasis. However, whether FGF14-AS2 plays a role in the bone metastasis...
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Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis
The objective of the present study was to review the molecular mechanisms of the adverse effects of environmental pollutants on chondrocytes and...
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Rheb1 is required for limb growth through regulating chondrogenesis in growth plate
Ras homology enriched in the brain (Rheb) is well established as a critical regulator of cell proliferation and differentiation in response to growth...
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Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals
Normal calciumCalcium and bone homeostasis in the adult is virtually fully explained by the interactions of several key regulatory hormones,...
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The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification
Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly...
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Exosomes in the pathogenesis and treatment of cancer-related cachexia
Cancer-related cachexia is a metabolic syndrome characterized by weight loss, adipose tissue decomposition, and progressive skeletal muscle atrophy....
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Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis
Bone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites...
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New Developments in Targeting Cancer Cachexia
Within the cancer population, 50–80% of patients will develop cachexia, impacting negatively on their ability to tolerate or gain benefit from either...
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Molecular-Genetic Bases of Mammary Gland Development Using the Example of Cattle and Other Animal Species: I. Embryonic and Pubertal Developmental Stage
AbstractThe growing demand of society for the products of farm animals entails continuous modernization of breeding programs. In order to improve the...
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Phytochemicals in Breast Cancer-Induced Osteoclastogenesis and Bone Resorption: Mechanism and Future Perspective
Most breast cancer patients develop bone metastasis and bone-related complications at the late stage of the disease irrespective of the subtypes....
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Expression of phosphate and calcium transporters and their regulators in parotid glands of mice
The concentration of inorganic phosphate (Pi) in plasma is under hormonal control, with deviations from normal values promptly corrected to avoid...
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Circ-RNF111 Promotes Proliferation of Ovarian Cancer Cell SKOV-3 by Targeting the MiR-556-5p/CCND1 Axis
The aim of this study was to investigate the role and mechanism of circ-RNF111 in the human ovarian cancer cell line SKOV-3. First, qRT-PCR was used...
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Molecular Mechanisms of Metastasis to the Bone
Bone metastasis is an incurable and lethal aspect of many advanced-stage malignancies that significantly impacts patient quality of life. Although it...
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Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer
BackgroundCentromere Protein F (CENPF) associates with the centromere–kinetochore complex and influences cell proliferation and metastasis in several...
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Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage
Pericytes are pluripotent cells that enclose the endothelium of small blood vessels in the whole body. These cells are thought to play a limited role...
