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Anti-inflammatory effects of PRIMA-1MET (mutant p53 reactivator) induced by inhibition of nuclear factor-κB on rheumatoid arthritis fibroblast-like synoviocytes
Fibroblast-like synoviocytes (FLSs), the main pathological cells in rheumatoid arthritis (RA), display tumor-like phenotype, including...
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PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level
BackgroundNeuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its...
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AMPK/MTOR/TP53 Signaling Pathway Regulation by Calcitonin Gene-Related Peptide Reduces Oxygen-Induced Lung Damage in Neonatal Rats through Autophagy Promotion
Our previous studies indicated that calcitonin gene-related peptide (CGRP) alleviates hyperoxia-induced lung injury and suggested the possible...
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Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial
Poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as maintenance therapy after first-line chemotherapy have improved progression-free...
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The Time Profile of the Effects of Moderate Hypothermia on Synaptic Acetylcholinesterase in Rat Brain
Hypothermia in homeotherms significantly affects the neurotransmitter systems of the brain, including the cholinergic system. The function of the...
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p53 biology and reactivation for improved therapy in MDS and AML
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) originate from preleukemic hematopoietic conditions, such as clonal hematopoiesis of...
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Electronic Visual Prostheses
Electronic retinal implants represent a promising technology for partial restoration of vision in severe neurodegenerative diseases. The underlying...
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Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness
The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial...
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Drugging p53 in cancer: one protein, many targets
Mutations in the TP53 tumour suppressor gene are very frequent in cancer, and attempts to restore the functionality of p53 in tumours as a...
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Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors
Retinal prostheses could restore image-forming vision in conditions of photoreceptor degeneration. However, contrast sensitivity and visual acuity...
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Efficacy of front-line immunochemotherapy for follicular lymphoma: a network meta-analysis of randomized controlled trials
Front-line treatment for follicular lymphoma has evolved with the introduction of maintenance therapy, bendamustine (Benda), obinutuzumab (G), and...
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Semantic Analyses of Hilary Putnam’s Twin Earth (Ft. TE Diagram)
Hilary Putnam is one of the most productive thought experimenters of contemporary analytical philosophy. Next to Brain in a Vat as derived from some...
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Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
Emerging of reactive oxygen species (ROS) on the earth with the first oxygen molecule in the atmosphere around 2.4–3.8 billion years ago, and they...
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Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
Emerging of reactive oxygen species (ROS) on the earth with the first oxygen molecule in the atmosphere around 2.4–3.8 billion years ago, and they...
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EZH2 mutations at diagnosis in follicular lymphoma: a promising biomarker to guide frontline treatment
EZH2 is mutated in nearly 25% of follicular lymphoma (FL) cases. Little is known about how EZH2 affects patients’ response to therapy. In this...
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The Malaysian Society of Toxicology: from establishment to evolution, a promising future!
The Malaysian Society of Toxicology (MySOT), founded in 2010, emerged as a response to the growing need for a collective and interdisciplinary effort...
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Der gute Riecher der Tiere
Die Nase spielt im Tierreich eine zentrale Rolle. Sie erkennt Gefahren, findet Nahrung und den richtigen Partner. Unter den Säugetieren hat der...
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