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Immunological Assessment of Chitosan or Trimethyl Chitosan-Coated PLGA Nanospheres Containing Fusion Antigen as the Novel Vaccine Candidates Against Tuberculosis
The crucial challenge in tuberculosis (TB) as a chronic infectious disease is to present a novel vaccine candidate that improves current vaccination...
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Validation of Multi-epitope Peptides Encapsulated in PLGA Nanoparticles Against Influenza A Virus
Abstract BackgroundInfluenza is a highly contagious respiratory disease which poses a serious threat to public health globally, causing severe...
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PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives
Research on cancer treatment is always of great importance because of the extensive and difficult treatment options and side effects of...
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PLGA Nanoparticles as an Efficient Platform in Protein Vaccines Against Toxoplasma gondii
BackgroundToxoplasma gondii ( T. gondii ) as an obligatory intracellular is widespread all over the world and causes considerable concerns in...
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Puerarin Loaded PLGA Nanoparticles: Optimization Processes of Preparation and Anti-alcohol Intoxication Effects in Mice
To improve the bioavailability of puerarin in liver, the optimized preparation method of puerarin-PLGA nanoparticles (Pue-PLGA-nps) and the effect of...
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Revolutionizing the Treatment of Idiopathic Pulmonary Fibrosis: From Conventional Therapies to Advanced Drug Delivery Systems
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease that has been well-reported in the medical literature. Its...
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Development and In Vitro Evaluation of Crizotinib-Loaded Lipid–Polymer Hybrid Nanoparticles Using Box–Behnken Design in Non-small Cell Lung Cancer
The goal of the study was to produce, optimize, characterize, and compare crizotinib-loaded lipid-polymer hybrid nanoparticles (CL-LPHNPs),...
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Quality-by-Design Based Development of Doxycycline Hyclate–Loaded Polymeric Microspheres for Prolonged Drug Release
This study explores a novel approach to address the challenges of delivering highly water-soluble drug molecules by employing hydrophobic ion-pairing...
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Regeneration of Rat Sciatic Nerve Using PLGA Conduit Containing Rat ADSCs with Controlled Release of BDNF and Gold Nanoparticles
Implantation of a nerve guidance conduit (NGC) carrying neuroprotective factors is promising for repairing peripheral nerve injury. Here, we...
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Nanoparticles Solutions for Allergic Airway Disorders: Current Trends and Future Prospects
The present work explores the world of nanoparticles as a potential solution, for addressing allergic airway diseases. The ailments, such as asthma...
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Routes of Nano-drug Administration and Nano-based Drug Delivery System and Toxicity
In recent years, nanotechnology has grown significantly with enormous potential in technology in research and medicine to improve tissue engineering,...
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Future Perspectives of PLGA Nanospheres for Advanced DDSs and Continuous Preparation Systems for Spherical Crystallizers
Application of PLGA NSs for drug-eluting medical devices and mixed suspension, mixed product removal (MSMPR) crystallizers.
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Development of a PLGA-Nanosphere DDS Prepared by Spherical Crystallization with a Polymer
In this chapter, we developed biocompatible and biodegradable polymeric micro/nanospheres using PLGA, loaded with a bioactive substance to create...
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Differential effects of rat ADSCs encapsulation in fibrin matrix and combination delivery of BDNF and Gold nanoparticles on peripheral nerve regeneration
BackgroundFibrin as an extracellular matrix feature like biocompatibility, creates a favorable environment for proliferation and migration of cells...
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Advances in Nanotechnology for Drug Delivery Modulation in Neurodegenerative Diseases
As aging populations continue to grow due to the increased life expectancy, neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s...
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Polymeric Nanoparticles-Based Drug Delivery Systems for Anticancer Therapy
Cancer, a large group of diseases, remains the major cause of morbidity and mortality across the globe and is characterized by uncontrolled cell...
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Nanomedicines for the Treatment of Systemic Candidiasis
Systemic candidiasis is a serious infection impacting several parts of the body. Opportunistic fungi belonging to the Candida genus can potentially...
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Role of Block Copolymers in Vaccines
Block copolymers are segments of two or more polymers connected through covalent bonds. These polymers enable various features such as wetting,...
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Nanomedicines Obtained by 3D Printing
Nanomedicine encompasses the use of nanotechnology for medical applications. The development of nano-based drug delivery systems has revealed new...
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Nanocapsule Delivery of IL-12
Interleukin(IL)-12 is a protein that activates T cellsT cells and macrophages to kill tumor cells. However, despite this cytokine showing strong...