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The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis
The light-sensitive outer segment organelle of photoreceptor cells contains a stack of hundreds of flat, disc-shaped membranes called discs. The rims...
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Absence of PRCD Leads to Dysregulation in Lipid Homeostasis Resulting in Disorganization of Photoreceptor Outer Segment Structure
The outer segments of photoreceptors are specialized sensory cilia crucial for light detection. Any disruption that alters outer segment morphology...
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Trends in Formulation Approaches for Sustained Drug Delivery to the Posterior Segment of the Eye
The eye, an intricate organ comprising physical and physiological barriers, poses a significant challenge for ophthalmic physicians seeking to treat...
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Targeting Outer Membrane to Tackle Multidrug-Resistant Bacterial Pathogens
Infections caused due to Gram-negative bacterial pathogens, under community as well as nosocomial settings, are increasing affecting healthcare...
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The Metabolism of 2-arachidonoylglycerol in Rod Outer Segments Is Modulated by Proteins Involved in the Phototransduction Process
We previously reported that 2-arachidonoylglycerol (2-AG) synthesis by diacylglycerol lipase (DAGL) and lysophosphatidate phosphohydrolase (LPAP) and...
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Tissue-Segment Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor’s Natural Environment
The pharmacological and biochemical properties of G protein-coupled receptors have been recently revealed to be more complex than originally...
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Putative novel outer membrane antigens multi-epitope DNA vaccine candidates identified by Immunoinformatic approaches to control Acinetobacter baumannii
Multi-epitope polypeptide vaccines, a fusion protein, often have a string-of-beads system composed of various specific peptide epitopes, potential...
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Ophthalmic dosage forms for drug delivery to posterior segment
BackgroundDegenerative ocular diseases such as macular retinopathy and retinal disorders significantly affect vision loss and the quality of life....
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Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
The axon initial segment (AIS) is a highly specialized axonal compartment where the action potential is initiated. The heterogeneity of AISs has been...
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Acute and continuous exposure of airborne fine particulate matter (PM2.5): diverse outer blood–retinal barrier damages and disease susceptibilities
BackgroundThe association between air pollution and retinal diseases such as age-related macular degeneration (AMD) has been demonstrated, but the...
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A Ciliary Branched Actin Network Drives Photoreceptor Disc Morphogenesis
The light-detecting organelle of the photoreceptor cell is a modified primary cilium, called the outer segment. The outer segment houses hundreds of...
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Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
PurposeWe assessed the potential effect of CoQ10 administration for the prevention of contrast induced-acute kidney injury (CI-AKI) in patients with...
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Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy
Photoreceptors are highly polarized sensory neurons. Precise localization of signaling molecules within the ciliary outer segment is critical for...
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In vivo evaluation of a Nano-enabled therapeutic vitreous substitute for the precise delivery of triamcinolone to the posterior segment of the eye
This study focused on the design of a thermoresponsive, nano-enabled vitreous substitute for the treatment of retinal diseases. Synthesis of a...
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In vitro dissolution testing models of ocular implants for posterior segment drug delivery
The delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal...
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Ceratocolax tavaresi n. sp. (Copepoda: Bomolochidae) parasitic in the Tomtate Grunt Haemulon aurolineatum Cuvier, 1830 (Actinopterygii: Haemulidae) off Rio de Janeiro, southeastern Brazil
PurposeA new species of the genus Ceratocolax Vervoort, 1965 is described based on specimens collected from the Tomtate grunt Haemulon aurolineatum ...
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The Histopathology of Severe Graded Compression in Lower Thoracic Spinal Cord Segment of Rat, Evaluated at Late Post-injury Phase
Spontaneous recovery of lost motor functions is relative fast in rodent models after inducing a very mild/moderate spinal cord injury (SCI), and this...
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Identification of the zebrafish homologues of IMPG2, a retinal proteoglycan
Photoreceptor outer segments are surrounded by a carbohydrate-rich matrix, the interphotoreceptor matrix, necessary for physiological retinal...
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In Silico Prediction of MYO1C-Rhodopsin Interactions and Its Significance in Protein Localization and Visual Function
Rods and cones are photoreceptor neurons in the retina that are required for visual sensation in vertebrates, where proper protein localization and...
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Genetic and phylogenetic characterization of polycistronic dsRNA segment-10 of bluetongue virus isolates from India between 1985 and 2011
The smallest polycistronic dsRNA segment-10 (S10) of bluetongue virus (BTV) encodes NS3/3A and putative NS5. The S10 sequence data of 46 Indian BTV...
