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Expression of p52, a non-canonical NF-kappaB transcription factor, is associated with poor ovarian cancer prognosis
BackgroundThe canonical and non-canonical nuclear factor-kappaB (NF-κB) signaling pathways have key roles in cancer, but studies have previously...
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Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway
BackgroundRearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a...
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LncRNA MTC-p65 Protein Mediates Skin Fibroblast Proliferation in Liaoning Cashmere Goat by Regulating the Nuclear Factor-Kappa B Signaling Pathway
The aim of this study is to investigate the activation of NF-κB signaling pathway and the regulation of the expression of genes related to chorionic...
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Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much...
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Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)
BackgroundThe polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged...
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Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis
Cadmium is an environmental pollutant that constitutes a major danger to human health. It is considered a definite human carcinogen. The lung and...
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Immune Response Gene-1 [IRG1]/itaconate protect against multi-organ injury via inhibiting gasdermin D-mediated pyroptosis and inflammatory response
Sepsis is a multiple organ dysfunction syndrome due to a dysregulated response to infection with unacceptably high mortality. Currently, no effective...
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Serum metabolomics profiling by proton nuclear magnetic resonance spectrometry of the response to single oral macronutrient challenges in women with polycystic ovary syndrome (PCOS) compared with male and female controls
BackgroundThe polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged...
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Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules
Flavipin, a fungal lower molecular weight biomolecule (MW 196.16 g/mol), has not been yet extensively studied for beneficial preclinical and clinical...
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Protective effects of Stephania pierrei tuber-derived oxocrebanine against LPS-induced acute lung injury in mice
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) have high mortality rates. Though corticosteroids are commonly used for the...
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LncRNA H19 Regulates P-glycoprotein Expression Through the NF-κB Signaling Pathway in the Model of Status Epilepticus
Pharmaco-resistance is a challenging problem for treatment of status epilepticus (SE) in the clinic. P-glycoprotein (P-gp) is one of the most...
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Anti-inflammatory effects of PRIMA-1MET (mutant p53 reactivator) induced by inhibition of nuclear factor-κB on rheumatoid arthritis fibroblast-like synoviocytes
Fibroblast-like synoviocytes (FLSs), the main pathological cells in rheumatoid arthritis (RA), display tumor-like phenotype, including...
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Advanced Glycation End Products in Diabetes
Advanced glycation end products (AGEs) are the product of the interaction of sugars and other glycation inducers with proteins, nucleic acids, and...
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Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway
BackgroundAcute pancreatitis (AP) is an inflammatory process of the pancreas resulting from biliary obstruction or alcohol consumption....
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2
Androgen excess and metabolic abnormality largely contribute to the pathogenesis of polycystic ovarian syndrome (PCOS), which primarily precipitates...
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Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation
BackgroundCigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many...
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Advanced Glycation End Products in Diabetes
Advanced glycation end products (AGEs) are the product of the interaction of sugars and other glycation inducers with proteins, nucleic acids, and...
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Treatment with protocatechuic acid attenuates cisplatin-induced toxicity in the brain and liver of male Wistar rats
This study investigated the ameliorative effect of protocatechuic acid (PCA) in oxidative stress induced by cisplatin (CPL) in the brain and liver of...
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Sinensetin Attenuates Amyloid Beta25-35-Induced Oxidative Stress, Inflammation, and Apoptosis in SH-SY5Y Cells Through the TLR4/NF-κB Signaling Pathway
Sinensetin (SIN) is an important active compound that exists widely in citrus plants, and has been reported to exhibit various pharmacological...
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Unraveling the Intricacies of OPG/RANKL/RANK Biology and Its Implications in Neurological Disorders—A Comprehensive Literature Review
The OPG/RANKL/RANK framework, along with its specific receptors, plays a crucial role in bone remodeling and the functioning of the central nervous...
