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A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments
This historical review traces key discoveries regarding K + and Na + ions in skeletal muscle at rest and with exercise, including contents and...
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Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo
BackgroundGlycolytic flux is regulated by the energy demands of the cell. Upregulated glycolysis in cancer cells may therefore result from increased...
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Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium
BackgroundNonthyroidal Illness Syndrome (NTIS) can be detected in many critical illnesses. Recently, we demonstrated that this condition is...
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Screening of Peptides that Specifically Binds to M3-M4 Extracellular Domain of Sodium Pump α1 Subunit and Analysis of Their Bioactivity In Vitro and In Vivo
Interaction between ouabain (OUA) and Na + /K + -pump remains in the current focus of hypertension research. This study aimed to find an oligopeptide...
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LPS-induced impairment of Na+/K+-ATPase activity: ameliorative effect of tannic acid in mice
Acetylcholine is an excitatory neurotransmitter that modulates synaptic plasticity and communication, and it is essential for learning and memory...
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Exercise and fatigue: integrating the role of K+, Na+ and Cl− in the regulation of sarcolemmal excitability of skeletal muscle
Perturbations in K + have long been considered a key factor in skeletal muscle fatigue. However, the exercise-induced changes in K + ...
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Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
Na + /K + -ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is...
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Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy
The marine flavobacterium Krokinobactereikastus light-driven sodium pump (KR2) generates an outward sodium ion current under 530 nm light...
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Na+-K+-2Cl− Cotransporter
The conceptual breakthrough that the energy of the Na+ gradient generated by the Na+/K+ ATPase (pump) could be used as the driving force for another...
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Bacterial Drug Efflux Pump Inhibitors from Plants
The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health, food security, and development. Drug-resistant...
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Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na+-dependent transport
Increases in the current threshold occur in optic nerve axons with the application of infra-red laser light, whose mechanism is only partly...
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Effects of Long-Acting Testosterone Undecanoate on Behavioral Parameters and Na + , K+-ATPase mRNA Expression in Mice with Alzheimer`s Disease
Previous studies have shown that testosterone attenuates stress-induced mood dysfunction and memory deterioration. However, the exact mechanism is...
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Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs
Aconitine (ACO), a main active ingredient of Aconitum , is well-known for its cardiotoxicity. However, the mechanisms of toxic action of ACO remain...
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Implications of Sarcolemmal Ca2+-Handling Proteins in Heart Function in Health and Disease
A small amount of Ca2+ enters the cell through the sarcolemmal membrane, releases an additional amount of Ca2+ from the sarcoplasmic reticulum, and...
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Protective Effects of Inosine on Memory Consolidation in a Rat Model of Scopolamine-Induced Cognitive Impairment: Involvement of Cholinergic Signaling, Redox Status, and Ion Pump Activities
AbstractThis study investigated the effects of inosine on memory acquisition and consolidation, cholinesterases activities, redox status and Na + , K + -...
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Carrier-Mediated Transport
The sensitivity of modern voltage-clamp techniques allows detection of carrier-mediated transport provided that a large membrane surface is...
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MRI-guided robot intervention—current state-of-the-art and new challenges
Magnetic Resonance Imaging (MRI) is now a widely used modality for providing multimodal, high-quality soft tissue contrast images with good...
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The influence of hyperpolarization-activated cation current on conduction delay and failure of action potentials along axon related to abnormal functions
Conduction delay and failure behaviors of action potentials with a high frequency along nerve fiber are related to the abnormal functions. For...
