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Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis
AbstractThe outbreak of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus...
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Screening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: molecular modeling and molecular dynamics studies
COVID-19, the current global pandemic has caused immense damage to human lives and the global economy. It is instigated by the SARS-CoV-2 virus and...
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SARS-CoV-2: analysis of the effects of mutations in non-structural proteins
A worldwide pandemic that started in China in late 2019 was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded...
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COVID-19: An Overview of Virology, Mutations, Pathology, Epidemiology, Diagnosis, Preventions, and Treatments
Since the first case of coronavirus disease (COVID-19) was reported in December 2019, it has become a pandemic, which is one of the most severe...
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Possible role of autophagy induced by COVID-19 in cancer progression, chemo-resistance, and tumor recurrence
COVID-19 infection is a serious threat to patients with primary diseases, especially multiple cancers. Studies suggest that cancer patients are one...
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Monitoring SARS-CoV-2 variants in wastewater of Dhaka City, Bangladesh: approach to complement public health surveillance systems
BackgroundWastewater-based epidemiological surveillance has been considered a powerful tool for early detection and monitoring of the dynamics of...
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Role and clinical implication of autophagy in COVID-19
The ongoing coronavirus disease 2019 (COVID-19) pandemic constitutes a serious public health concern worldwide. Currently, more than 6 million deaths...
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Evidence of SARS-CoV-2 convergent evolution in immunosuppressed patients treated with antiviral therapies
BackgroundThe factors contributing to the accelerated convergent evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not...
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Global landscape of SARS-CoV-2 mutations and conserved regions
BackgroundAt the end of December 2019, a novel strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been...
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LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19
BackgroundSyndrome coronavirus-2 (SARS-CoV-2) has developed various strategies to evade the antiviral impact of type I IFN. Non-structural proteins...
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Antiviral Phytocompounds Against Animal-to-Human Transmittable SARS-CoV-2
Pandemics of lethal coronaviruses have created huge challenges to healthcare systems over the last few years. The fast proliferation of severe acute...
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Whole genome sequence of an uncommon G9P[4] species A rotavirus containing DS-1-like (genotype 2) genes in Japan
Species A rotaviruses (RVAs) have been recognized as one of the leading causes of acute gastroenteritis in humans worldwide. Here, the complete...
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SARS-CoV-2 Mutations Lead to a Decrease in the Number of Tissue-Specific MicroRNA-Binding Regions in the Lung
RNA interference in vertebrates acts as an antiviral mechanism only in undifferentiated embryonic stem cells and is mediated by microRNAs. In somatic...
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Interferon antagonists encoded by SARS-CoV-2 at a glance
The innate immune system is a powerful barrier against invading pathogens. Interferons (IFNs) are a major part of the cytokine-mediated anti-viral...
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Functions of MAP3Ks in antiviral immunity
Immune signal transduction is crucial to the body’s defense against viral infection. Recognition of pathogen-associated molecular patterns by pattern...
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Insights into In Silico Methods to Explore Plant Bioactive Substances in Combating SARS-CoV-2
SARS-CoV-2 is a virus belonging to the species “severe acute respiratory syndrome-related coronavirus” (SARSr-CoV), a strain that causes the...
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Evolutionary trajectory of SARS-CoV-2 and emerging variants
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more recently, the independent evolution of...
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Evidence of natural selection and dominance of SARS-CoV-2 variant Lambda (C.37) over variants of concern in Cusco, Peru
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage C.37 (Lambda) has spread rapidly in Peru and other Latin American countries....
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Evolution of the SARS-CoV-2 genome and emergence of variants of concern
The high transmission and mortality rates associated with SARS-CoV-2 have led to tragic consequences worldwide. Large-scale whole-genome sequencing...
