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Novel role of immune-related non-coding RNAs as potential biomarkers regulating tumour immunoresponse via MICA/NKG2D pathway
Major histocompatibility complex class I related chain A (MICA) is an important and stress-induced ligand of the natural killer group 2 member D...
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Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer
BackgroundAdoptive cell therapy has achieved great success in treating hematological malignancies. However, the production of chimeric antigen...
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Distinctive CD56dim NK subset profiles and increased NKG2D expression in blood NK cells of Parkinson’s disease patients
Mounting data suggest an important role for the immune system in Parkinson’s disease (PD). Previous evidence of increased natural killer (NK) cell...
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Association of inhibitory NKG2A and activating NKG2D natural killer cell receptor genes with resistance to SARS-CoV-2 infection in a western Indian population
We have evaluated the association of polymorphisms in the intronic variable-number tandem repeat (VNTR) regions of the human NKG2D , NKG2A , and IL-1RN ...
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NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma
CAR-T-cell therapy against MM currently shows promising results, but usually with serious toxicities. CAR-NK cells may exert less toxicity when...
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A novel approach for relapsed/refractory FLT3mut+ acute myeloid leukaemia: synergistic effect of the combination of bispecific FLT3scFv/NKG2D-CAR T cells and gilteritinib
BackgroundPatients with relapsed/refractory acute myeloid leukaemia (AML) with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) have...
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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen receptor (γδ TCR)-mediated cancer...
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High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumor
BackgroundNon-muscle-invasive bladder cancer (NMIBC) is treated with transurethral resection of bladder tumor (TURBT) followed by intravesical...
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Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlow T cells
BackgroundPsoriasis is a chronic immune-mediated skin condition. Although biologic treatments are effective in controlling psoriasis, some patients...
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Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer
BackgroundThe impact of non-small cell lung cancer (NSCLC) metabolism on the immune microenvironment is not well understood within platinum...
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Ex vivo expanded allogeneic natural killer cells have potent cytolytic activity against cancer cells through different receptor-ligand interactions
BackgroundRecently, allogeneic natural killer (NK) cells have gained considerable attention as promising immunotherapeutic tools due to their unique...
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Defining the role of natural killer cells in COVID-19
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have therefore sought to characterize the NK cell response to...
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Communication in miRNAs Between Inflammation and Cancer
Inflammatory and immune responses are controlled by microRNAs (miRNAs), and cancer is also regulated by miRNAs. Computing analysis and evidence from...
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MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis
Ankylosing spondylitis (AS) is an autoinflammatory disease that affects the sacroiliac joints, causing stiffness and pain in the back. MICA is a...
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Different endurance exercises modulate NK cell cytotoxic and inhibiting receptors
PurposeInduction of IDO depends on the activation of AhR forming the AhR/IDO axis. Activated AhR can transcribe various target genes including...
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A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity
Virtual memory T (T VM ) cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. Although T VM cells have antiviral...
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Updated Clinical Perspectives and Challenges of Chimeric Antigen Receptor-T Cell Therapy in Colorectal Cancer and Invasive Breast Cancer
In recent years, the incidence of colorectal cancer (CRC) and breast cancer (BC) has increased worldwide and caused a higher mortality rate due to...
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Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions
T lymphocytes comprise cells expressing either an αβ or a γδ TCR. The riddle how αβ TCRs are triggered by specific peptides presented in the context...
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Effect of different cytokines in combination with IL-15 on the expression of activating receptors in NK cells of patients with Behçet’s disease
Behçet’s disease (BD) is a systemic, autoinflammatory, chronic disorder which affects various parts of the body in genetically susceptible...
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Dynamic changes of phenotype and function of natural killer cells in peripheral blood before and after thermal ablation of hepatitis B associated hepatocellular carcinoma and their correlation with tumor recurrence
BackgroundThermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural...
