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Intestinal mucus components and secretion mechanisms: what we do and do not know
Damage to the colon mucus barrier, the first line of defense against microorganisms, is an important determinant of intestinal diseases such as...
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The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine
The intestinal epithelium is covered by mucus that protects the tissue from the luminal content. Studies have shown that anion secretion via the...
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Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria
The breakdown of the gut’s mucosal barrier that prevents the infiltration of microorganisms, inflammatory cytokines and toxins into bodily tissues...
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Reduced acetylcholine and elevated muscarinic receptor 2 in duodenal mucosa contribute to the impairment of mucus secretion in 6-hydroxydopamine-induced Parkinson’s disease rats
Patients with Parkinson’s disease (PD) have a higher incidence rate of duodenal ulcers. The mucus barrier provides the first line of defense for...
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Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets
Early intervention and short-duration treatments with antibiotics in premature infants are reported to reduce the incidence of necrotizing...
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PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model
BackgroundTyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide...
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A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems
The gastrointestinal mucus barrier is a widely overlooked yet essential component of the intestinal epithelium, responsible for the body’s protection...
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Macrophage-intrinsic DUOX1 contributes to type 2 inflammation and mucus metaplasia during allergic airway disease
The NADPH oxidase DUOX1 contributes to epithelial production of alarmins, including interleukin (IL)-33, in response to injurious triggers such as...
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Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis
Ulcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by high incidence and young onset age. Recently, there...
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Bicarbonate secretion and acid/base sensing by the intestine
The transport of bicarbonate across the enterocyte cell membrane regulates the intracellular as well as the luminal pH and is an essential part of...
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Metagenomes of rectal swabs in larger, advanced stage cervical cancers have enhanced mucus degrading functionalities and distinct taxonomic structure
BackgroundGut microbiome community composition differs between cervical cancer (CC) patients and healthy controls, and increased gut diversity is...
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Mucus composition abnormalities in sinonasal mucosa of chronic rhinosinusitis with and without nasal polyps
Mucus secretion and its composition are vital in the maintenance of airway health, among which hypoxia-inducible factors (HIFs) are thought to be...
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Aquaporins in Glandular Secretion
Exocrine and endocrine glands deliver their secretory product, respectively, at the surface of the target organs or within the bloodstream. The...
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Macrolides and Inflammatory Cells, Signaling, and Mediators
Low-dose long-term macrolide therapy had a remarkable effect on the prognosis of diffuse panbronchiolitis and suppression of airway secretion and...
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Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion
Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to environmental insult, has a critical role in initiating airway...
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SOX9 Promotes Collagen VI Secretion by Upregulating PCOLCE in Neurofibroma
Neurofibromatosis type 1 (NF1) is caused by NF1 gene mutations. Patients with NF1 often have complications with tumors, such as neurofibroma. In...
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Snail mucus from the mantle and foot of two land snails, Lissachatina fulica and Hemiplecta distincta, exhibits different protein profile and biological activity
ObjectiveSnails secrete different types of mucus that serve several functions, and are increasingly being exploited for medical and cosmetic...
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H1-Receptor Antagonist Olopatadine Inhibits MUC5AC Secretion by Conjunctival Goblet Cells
The study examined the effect of H1-receptor antagonist olopatadine on the secretory function of cultured rat conjunctival goblet cells (CGC)...
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Three Main SCFAs Mitigate Lung Inflammation and Tissue Remodeling Nlrp3-Dependent in Murine HDM-Induced Neutrophilic Asthma
Neutrophilic asthma is generally defined by poorly controlled symptoms and high levels of neutrophils in the lungs. Short-chain fatty acids (SCFAs)...
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Characterisation by Excitation-Emission Matrix Fluorescence Spectroscopy of Pigments in Mucus Secreted of Earthworm Eisenia foetida Exposed to Lead
The earthworm exposed to toxics shows physiological responses as: avoidance and mucus secretion. Heavy metals are particularly toxic to earthworms...
