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Exosomal lncRNA UCA1 modulates cervical cancer stem cell self-renewal and differentiation through microRNA-122-5p/SOX2 axis
BackgroundThere is growing evidence discussing the role of long non-coding RNAs (lncRNAs) in cervical cancer (CC). We performed this study to explore...
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MicroRNA-122-5p inhibits cell proliferation, migration and invasion by targeting CCNG1 in pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal human malignancy, and previous researches support the contribution of microRNA (miRNA)...
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Uncovering essential anesthetics-induced exosomal miRNAs related to hepatocellular carcinoma progression: a bioinformatic investigation
BackgroundAnesthetic drugs may alter exosomal microRNA (miRNA) contents and mediate cancer progression and tumor microenvironment remodeling. Our...
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MiR-122-5p suppresses neuropathic pain development by targeting PDK4
The complex pathogenesis and limited efficacy of available treatment make neuropathic pain difficult for long periods of time. Several findings...
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MiRNA Immunity Against Virus and MiRNA Surveillance Against Tumor
Through the microRNA (miRNA) entangling target sorting/quantum miRNA language plus artificial intelligence (METS/MIRAI) analysis so far, it seems...
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MicroRNAs in Cancer: Diagnostics and Therapeutics
Tumor initiation, recurrence, progression, and spread of cancer are multistep processes which involve numerous molecular and cellular mechanisms. One...
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Diagnostic, Prognostic and Theranostic Potential of miRNAs in Prostate Cancer
A novel class of gene regulators, small noncoding RNAs or microRNAs (miRNAs) has an important role in various malignancies, including prostate cancer...
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MicroRNAs as Potential Biomarkers in Huntington’s Disease
MicroRNAs (miRNAs) play an essential role in many physiological processes of our body. Dysregulation of miRNAs is involved in the pathology of...
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Trimethylamine-N-oxide, a New Risk Factor for Non-alcoholic Fatty Liver Disease Changes the Expression of miRNA-34a, and miRNA-122 in the Fatty Liver Cell Model
Non-alcoholic fatty liver disease is a multifactorial disorder with complicated pathophysiology ranging from simple steatosis to steatohepatitis and...
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CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
BackgroundAlthough papillary thyroid carcinoma (PTC) has a favorable prognosis, it could affect patient life quality and become a serious threat...
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The Implication of Liquid Biopsy in the Non-small Cell Lung Cancer: Potential and Expectation
Nowadays, lung cancer has remained the most lethal cancer, despite great advances in diagnosis and treatment. However, a large proportion of patients...
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Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs
Spinal cord injury (SCI) is an unfortunate experience that may generate extensive sensory and motor disabilities due to the destruction and passing...
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MicroRNAs as Tools for Early Diagnosis and Predicting Responses to Therapy in Oesophageal Cancer
Oesophageal cancer (EC) is an aggressive and invasive cancer with limited diagnosis and survival. EC usually occurs as either oesophageal...
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Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis
Oxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the...
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Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers
Extracellular vesicles (EVs) are membrane enveloped particles released from cells to the extracellular environment and body fluids. During their...
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MicroRNAs in Cancer: Diagnostics and Therapeutics
Tumor initiation, recurrence, progression, and spread of cancer are multistep processes which involve numerous molecular and cellular mechanisms. One...
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Recent advances of exosomal circRNAs in cancer and their potential clinical applications
Circular RNA (circRNA) is a type of non-coding RNA that forms a covalently closed, uninterrupted loop. The expression of circRNA differs among cell...
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Etiology Analysis for Human Cancer
Although disease prediction by microRNAs (miRNAs) based on mathematical data science has been statistically validated, no disease prediction can...
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Metabolic Disease and Alzheimer’s Disease
Age-related diseases (ARDs) include inflammatory atherosclerosis and cardiovascular disease in coronary artery disease (CAD), hypertension, type 2...
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Encounter with the Unknown
The severe respiratory syndrome human coronavirus 2 (SARS-CoV-2) pandemic has forced us to recognize the need for rapid analysis of unknown viral...