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Single-organ pulmonary metastasis is a favorable prognostic factor in metastatic colorectal cancer patients treated with FOLFIRI and vascular endothelial growth factor inhibitors
BackgroundFew studies have focused on the impact of single-organ pulmonary metastases on progression-free survival and overall survival in patients...
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Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases
Glycosylation changes of cancer cells are known to be associated with malignant progression and metastases and potentially determine the...
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Comparative efficacy of combined CTLA-4 and PD-1 blockade vs. PD-1 monotherapy in metastatic melanoma: a real-world study
BackgroundIn light of the substantial toxicity associated with combined CTLA-4 and PD-1 blockade (ipilimumab and nivolumab), we assessed its efficacy...
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Hypoxia and the Metastatic Cascade
Metastasis is a leading cause of mortality in cancer patients. The journey of a detached primary tumour cell to a secondary homing site is a...
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of...
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Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program
Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program...
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A Systemic View of Metastatic Disease: Inter-Organ Crosstalk and Therapeutic Implications
As cancer progresses, the communication and crosstalk between cancer cells and the tumor microenvironment become a key determinant of successful...
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Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared...
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Immunotherapy in the Solid Organ Transplant Recipient
Checkpoint inhibitor immunotherapy has limited data in the immunosuppressed solid organ transplant recipient population as early use in this...
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Multi-organ landscape of therapy-resistant melanoma
Metastasis and failure of present-day therapies represent the most common causes of mortality in patients with cutaneous melanoma. To identify the...
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Intravital Microscopy of the Metastatic Pulmonary Environment
Real-time in vivo imaging has become an integral tool for the investigation and understanding of cellular processes in health and disease at...
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Pre-Metastatic Niche: Communication Between Local and Distal Onco-Spheres
The pre-metastatic niche (PMN) is a complex process of the “seed and soil” compatibility. The PMN microenvironment is formed by the influence of...
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Metastatic Disease of the Lung
Lung cancer remains a malignancy in which patients with metastatic disease have a much poorer prognosis compared to those without metastatic disease....
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Clinical significance of circulating-tumour DNA analysis by metastatic sites in pancreatic cancer
BackgroundLiquid biopsy is an alternative to tissue specimens for tumour genoty**. However, the frequency of genomic alterations with low...
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Current methods for studying metastatic potential of tumor cells
Cell migration and invasiveness significantly contribute to desirable physiological processes, such as wound healing or embryogenesis, as well as to...
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Medium-chain triglyceride-stabilized docetaxel-loaded HSA nanoparticles effectively inhibited metastatic non-small cell lung cancer
Metastatic non-small cell lung cancer (NSCLC) is refractory with a very poor prognosis. Docetaxel (DTX) injection (Taxotere ® ) has been approved for...
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Patients with metastatic renal cell carcinoma who receive immune-targeted therapy may derive survival benefit from nephrectomy
BackgroundNephrectomy, whether in the era of cytokine therapy or targeted therapy, has an important role in the treatment of metastatic renal cell...
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A new Neu—a syngeneic model of spontaneously metastatic HER2-positive breast cancer
Metastatic disease results from the dissemination of tumor cells beyond their organ of origin to grow in distant organs and is the primary cause of...
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Targeting Metastatic Disease: Challenges and New Opportunities
Metastasis is the major cause of cancer-associated deaths in most cancers. Research in the past two decades revealed the complexity of metastasis...
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Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on mortality rates....
