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Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis
PurposeMajor histocompatibility complex (MHC) class II deficiency is one of the combined immune deficiency disorders caused by defects in the MHC...
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The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and simple with few genes, most of...
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NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis
ObjectiveThis study was designed to investigate the role of the nucleotide-binding-domain -and leucine-rich repeat -containing (NLR) family,...
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Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception
BackgroundGastrointestinal malignancies encompass a diverse group of cancers that pose significant challenges to global health. The major...
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Major histocompatibility complex class I molecule expression by pancreatic cancer cells is regulated by activation and inhibition of the epidermal growth factor receptor
Pancreatic cancer is one of the deadliest neoplasms, with a dismal 5-year survival rate of only 10%. The ability of pancreatic cancer cells to evade...
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The Discovery of the Major Histocompatibility Complex (MHC): The H-2 in Mice and the HLA in Man
In this chapter I describe how the major histocompatibility system, the H-2 system, was discovered in mice by Peter Gorer in 1935 in London. This...
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The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation
The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA...
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Recurrent Infections in an Ethiopian Boy with Autosomal Recessive Major Histocompatibility Complex Type I Deficiency: a Case Report on a Very Rare Primary Immunodeficiency Disorder and a Review of Principles in Evaluation and Management
Little is known about major histocompatibility complex type I deficiency, a rare form of primary immunodeficiency. This report describes the...
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Induction of antigen-specific tolerance by nanobody–antigen adducts that target class-II major histocompatibility complexes
The association of autoimmune diseases with particular allellic products of the class-II major histocompatibility complex (MHCII) region implicates...
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Major Histocompatibility Complex Genes
Antigen binding by B cells occurs directly with the BCR recognizing epitopes on antigens. T cell recognition of antigens cannot occur unless the...
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Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis)
We performed a meta-analysis of the newly assembled Komodo dragon ( Varanus komodoensis ) genome to characterize the major histocompatibility complex...
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DNA-double strand breaks enhance the expression of major histocompatibility complex class II through the ATM-NF-κΒ-IRF1-CIITA pathway
Major histocompatibility complex class II (MHC II) is important for the adaptive immune response because MHC II presents processed antigens to a...
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Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice
BackgroundImmune molecules, such as cytokines, complement, and major histocompatibility complex (MHC) proteins, in the central nervous system are...
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IMGT/3Dstructure-DB: T-Cell Receptor TR Paratope and Peptide/Major Histocompatibility pMH Contact Sites and Epitope
T-cell receptors (TR), the antigen receptors of T cells, specifically recognize peptides presented by the major histocompatibility (MH) proteins, as...
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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
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Major histocompatibility complex (MHC) associations with diseases in ethnic groups of the Arabian Peninsula
Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of...
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Antigen-Presenting Cells and the Major Histocompatibility Complex
In this chapter, we will discuss the principles of antigen presentation. We will learn that the major purpose of antigen-presenting cells, such as...
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Dog leukocyte antigen genoty** across class I and class II genes in beagle dogs as laboratory animals
Dog leukocyte antigen (DLA) polymorphisms have been found to be associated with inter-individual variations in the risk, susceptibility, and severity...
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Prognostic and Clinical Significance of Human Leukocyte Antigen Class I Expression in Breast Cancer: A Meta-Analysis
BackgroundThe value of human leukocyte antigen (HLA; also known as major histocompatibility complex) class I expression for the prediction of breast...
