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Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway
Licochalcone A (Lico A), a flavonoid found in licorice, possesses multiple pharmacological activities in modulating oxidative stress, glycemia,...
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RPL15 promotes hepatocellular carcinoma progression via regulation of RPs-MDM2-p53 signaling pathway
BackroundRPL15 has been found to participate in human tumorigenesis. However, its function and regulatory mechanism in hepatocellular carcinoma (HCC)...
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Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway
BackgroundTargeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal...
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Functional interaction between S100A1 and MDM2 may modulate p53 signaling in normal and malignant endometrial cells
BackgroundS100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear.
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p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors
Targeting MDM2-p53 interaction has emerged as a promising antitumor therapeutic strategy. Several MDM2-p53 inhibitors have advanced into clinical...
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Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells
BackgroundDepletion of certain ribosomal proteins induces p53 activation, which is mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal...
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EVA1A reverses lenvatinib resistance in hepatocellular carcinoma through regulating PI3K/AKT/p53 signaling axis
Lenvatinib is a commonly used first-line drug for the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy is limited...
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P53, ROS: Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer
This chapter entitled “P53, ROS-Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer” initially shows P53 regulation with...
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The combination of Curcumin and Doxorubicin on targeting PI3K/AKT/mTOR signaling pathway: an in vitro and molecular docking study for inhibiting the survival of MDA-MB-231
The process of tumorigenesis is highly associated with the disruption of cell-cycle regulators and derangement of various signaling pathways, which...
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Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling
Hepatocellular carcinoma (HCC) is one of the most lethal tumours worldwide. However, the effects of first-line sorafenib treatment in advanced HCC...
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell...
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The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
BackgroundThe ATM kinase constitutes a master regulatory hub of DNA damage and activates the p53 response pathway by phosphorylating the MDM2...
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DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
BackgroundLung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to...
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Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma
The incidence of renal cell carcinoma (RCC) is increasing worldwide with an approximate 20% mortality rate. The challenge in RCC is the...
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Mechanisms of Oncogenesis
Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...
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Oncogenic signaling pathway mediated by Notch pathway-related genes induces immunosuppression and immunotherapy resistance in hepatocellular carcinoma
The Notch pathway is a highly conserved signaling pathway involved in the regulation of cell proliferation and differentiation. However, the...
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MDM2: current research status and prospects of tumor treatment
Mousedouble minute 2 (MDM2) is one of the molecules activated by p53 and plays an important role in the regulation of p53. MDM2 is generally believed...
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PELI1: key players in the oncogenic characteristics of pancreatic Cancer
BackgroundPancreatic cancer (PC) is a highly malignant gastrointestinal tumor, which is characterized by difficulties in early diagnosis, early...
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Mechanisms of Oncogenesis
Carcinogenesis can be due to replication errors, faulty repair of damaged DNA, and exposure to DNA-damaging agents. The two major carcinogenesis...