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P53, ROS: Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer

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Redox Regulation and Therapeutic Approaches in Cancer

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Abstract

This chapter entitled “P53, ROS-Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer” initially shows P53 regulation with MDM2, and its tumor suppressor role has been discussed through its activation/deactivation and apoptosis. Cellular redox homeostasis through the p53 antioxidant and prooxidant function has been discussed. As most cancers have mutant p53, its redox regulation functional changes have been discussed as gain of function (GOF) and loss of function (LOF) linking to cancer therapy. Further, p53 regulation of reprogramming of metabolism in cancer has been discussed both in wild type and mutant p53. p53-mediated, autophagy signaling pathways and regulation in cancer have also been taken up.

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  1. Department of Biophysics, Panjab University, Chandigarh, India

    Mohinder Pal Bansal

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Bansal, M.P. (2023). P53, ROS: Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer. In: Redox Regulation and Therapeutic Approaches in Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-99-7342-2_7

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