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Detection of melanoma, breast cancer and head and neck squamous cell cancer sentinel lymph nodes by Tc-99m Tilmanocept (Lymphoseek®)
Technetium-99m-labeled Tilmanocept or Lymphoseek® (Cardinal Health, Dublin, Ohio) is a soluble, synthetic molecule with a small diameter (7 nm),...
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Magnetic procedure for sentinel lymph node detection and evaluation of metastases: design and rationale of the Lowmag trial
BackgroundPrimary tumour biology and axillary lymph node status are key prognostic factors in breast cancer treatment. The LowMag trial introduced a...
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Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy
Sentinel lymph node biopsy (SLNB) is the international standard of care for providing prognostic information in cutaneous melanoma. This chapter...
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Nanoparticles labeled with gamma-emitting radioisotopes: an attractive approach for in vivo tracking using SPECT imaging
Providing accurate molecular imaging of the body and biological process is critical for diagnosing disease and personalizing treatment with the...
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Lymphedema: General Pathophysiology, Prevention, and Management in Invasive Cancer
Lymphedema is a common complication in cancer survivors. It results from lymphatic system injury due to lymphadenectomy, radio-, and chemotherapy. It...
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Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis
Imaging plays a crucial role in the fundamental understanding of lymphatic system structure and function throughout the body both in health and a...
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Sentinel Lymph Node Biopsy in Breast Cancer
Lymphatic metastasis is a strong predictor of poor outcome in breast cancer patients. Most often, lymphatic metastasis occurs through the axillary...
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Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlap** phenotypes
PurposeSeveral clinical phenotypes including fetal hydrops, central conducting lymphatic anomaly or capillary malformations with arteriovenous...
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Altered lymphatic drainage patterns in re-operative sentinel lymph node biopsy for ipsilateral breast tumor recurrence
BackgroundThis study aimed to evaluate the impact of previous local treatment on lymphatic drainage patterns in ipsilateral breast tumor recurrence...
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The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis
The lymphatic system is a complicated system consisting of the lymphatic vessels and lymph nodes draining the extracellular fluid containing cellular...
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Sentinel lymph node map** with superparamagnetic iron oxide for melanoma: a pilot study in healthy participants to establish an optimal MRI workflow protocol
BackgroundCurrent pre-operative Sentinel Lymph Node (SLN) map** using dual tracing is associated with drawbacks (radiation exposure, logistic...
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Secondary lymphedema from cancer therapy
This manuscript is a summary of findings focusing on various aspects of secondary lymphedema specifically as a sequelae of treatment for cancer. The...
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Cancer Nanomedicines in the Clinic: Coming of Age
Cancer is one of the diseases in which multimodality treatment is required. Despite the advances in the management strategies, improvement in...
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Donald L. Morton Memorial Lecture: the legacy of Donald Morton: past, present and future
Donald L. Morton, MD persevered against great odds throughout his life and career. Beginning in the humblest of circumstances, he worked his way to...
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Intraoperative electron radiotherapy in early invasive ductal breast cancer: 6-year median follow-up results of a prospective monocentric registry
BackgroundIntraoperative electron radiotherapy (IOERT) can be used to treat early breast cancer during the conservative surgery thus enabling shorter...
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Lymphedema self-assessment among endometrial cancer survivors
PurposeLower extremity lymphedema (LEL), which causes ankle, leg, and feet swelling, poses a significant challenge for endometrial cancer survivors,...
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Etiology and treatment of cancer-related secondary lymphedema
Lymphedema and specifically cancer-related lymphedema is not the main focus for both patients and physicians dealing with cancer. Its etiology is an...
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Pathologic Assessment of Lymph Node Metastasis
The pathologic assessment and evaluation of lymph node status plays a central role in the diagnosis, staging, and management of most malignancies....
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Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease
Diagnostic imaging is a cornerstone of cancer diagnosis, staging, assessment of treatment response, and long-term surveillance. The most appropriate...