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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis
BackgroundChronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow,...
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Stereotactic body radiotherapy for metastatic sarcoma to the lung: adding to the arsenal of local therapy
IntroductionConventional treatment of pulmonary metastatic sarcoma primarily involves surgery, with systemic therapy added in select patients....
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
PurposeFor patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared with many solid tumors....
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Hypoxia and the Metastatic Cascade
Metastasis is a leading cause of mortality in cancer patients. The journey of a detached primary tumour cell to a secondary homing site is a...
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A phase I study of the combination of atezolizumab, tiragolumab, and stereotactic body radiation therapy in patients with metastatic multiorgan cancer
BackgroundImmunotherapy targeting the PD-1/PD-L1 pathway is a standard of care in a number of metastatic malignancies, but less than a fifth of...
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Response to immune checkpoint inhibitor combination therapy in metastatic RET-mutated lung cancer from real-world retrospective data
BackgroundThe impact of immune checkpoint inhibitors (ICIs) based treatments on non-small cell lung cancers (NSCLCs) with RET fusions remains poorly...
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Synbiotics in Lung Cancer
Human microbiota has gained significant interest in the prevention and treatment of cancer. Synbiotics are profound examples of how microbiota can be...
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A Phase 2 study of nivolumab in combination with modified FOLFIRINOX for metastatic pancreatic cancer
BackgroundNivolumab with modified FOLFIRINOX (mFOLFIRINOX) may have additive antitumour effects while minimising chemotherapy cytotoxicity. We...
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of...
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Cancer treatments as paradoxical catalysts of tumor awakening in the lung
Much of the fatality of tumors is linked to the growth of metastases, which can emerge months to years after apparently successful treatment of...
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CTLA-4 Inhibitors for the Treatment of Lung Cancer
One of the most prevalent malignancies and the main reason for cancer-related deaths globally is lung cancer. The majority of these non-small-cell...
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Stereotactic body radiation therapy is beneficial for a subgroup of patients with urothelial cancer and solitary metastatic disease: a single institution real-world experience
BackgroundStandard treatment options for patients with metastatic urothelial cancer (mUC) include systemic platinum-based chemotherapy,...
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PMS2 amplification contributes brain metastasis from lung cancer
BackgroundLung adenocarcinoma metastasizing to the brain results in a notable increase in patient mortality. The high incidence and its impact on...
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Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial
Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic...
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Safety, efficacy and pharmacokinetics of BPI-9016M in c-MET overexpression or MET exon 14 skip** mutation patients with locally advanced or metastatic non-small-cell lung cancer: a phase Ib study
BackgroundAs a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor ( MET ) exhibits high aberrant expression across...
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Cell morphology best predicts tumorigenicity and metastasis in vivo across multiple TNBC cell lines of different metastatic potential
BackgroundMetastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate,...
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The incorporation of acetylated LAP-TGF-β1 proteins into exosomes promotes TNBC cell dissemination in lung micro-metastasis
Triple-negative breast cancer (TNBC) stands as the breast cancer subtype with the highest recurrence and mortality rates, with the lungs being the...
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How much do we know about the metastatic process?
Cancer cells can leave their primary sites and travel through the circulation to distant sites, where they lodge as disseminated cancer cells (DCCs),...
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Clinical outcomes and lung toxicities after lung SABR using dynamic conformal arc therapy: a single-institution cohort study
BackgroundStereotactic ablative radiotherapy (SABR) is a validated treatment for early stage lung cancer and pulmonary metastases. It provides a high...
