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Echinococcosis Immune Response, Immunopathogenesis and Immune Evasion from the Human Host
Echinococcosis is a worldwide parasitic disease with great harm and complicated immune mechanisms. Immunoprophylaxis is an ideal way to prevent...
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Evading the Antitumour Immune Response
The mutations that cause (or accompany) malignancy result in tumour cells being detected as “non-self” by the immune system and may evoke an...
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Immune Response to Staphylococcus aureus
Although Staphylococcus aureus is not a high virulent pathogen in healthy persons, this bacterium often persists in various tissues and mucosa and...
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Intrinsic immune evasion patterns predict temozolomide sensitivity and immunotherapy response in lower-grade gliomas
BackgroundAlthough intrinsic immune-evasion is important in cancer proliferation, metastasis and response to treatment, it is unclear whether...
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Immune Checkpoint Blockade Response Biomarkers
Cancer immunotherapy based on immune checkpoint blockade (ICB) has demonstrated durable clinical benefit in patients with immunogenic tumors,...
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Olfactory immune response to SARS-CoV-2
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory...
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Soluble immune checkpoints: implications for cancer prognosis and response to immune checkpoint therapy and conventional therapies
Longitudinal sampling of tumor tissue from patients with solid cancers, aside from melanoma and a few other cases, is often unfeasible, and thus may...
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The Behavioural Immune System of Lower Vertebrates
The immune system evolves under the ever-changing selective pressure of pathogens and its effective functioning involves not only immune-related...
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Immune response in influenza virus infection and modulation of immune injury by viral neuraminidase
Influenza A viruses cause severe respiratory illnesses in humans and animals. Overreaction of the innate immune response to influenza virus infection...
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An IFNγ-dependent immune–endocrine circuit lowers blood glucose to potentiate the innate antiviral immune response
Viral infection makes us feel sick as the immune system alters systemic metabolism to better fight the pathogen. The extent of these changes is...
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Host Immune Response to Scabies
Scabies infection is associated with heightened total IgE immunoglobulin and IgE antibodies to scabies antigens, with both being extremely high for...
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Macrophages coordinate immune response to laser-induced injury via extracellular traps
BackgroundRetinal degeneration results from disruptions in retinal homeostasis due to injury, disease, or aging and triggers peripheral leukocyte...
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Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
In cancer, evolutionary forces select for clones that evade the immune system. Here we analyzed >10,000 primary tumors and 356...
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The dengue-specific immune response and antibody identification with machine learning
Dengue virus poses a serious threat to global health and there is no specific therapeutic for it. Broadly neutralizing antibodies recognizing all...
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Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The...
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Phosphoflow cytometry to assess cytokine signaling pathways in peripheral immune cells: potential for inferring immune cell function and treatment response in patients with solid tumors
Tumor biopsy is often not available or difficult to obtain in patients with solid tumors. Investigation of the peripheral immune system allows for...
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Novel insights into the immune response to bacterial T cell superantigens
Bacterial T cell superantigens (SAgs) are a family of microbial exotoxins that function to activate large numbers of T cells simultaneously. SAgs...
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Humoral immune response and safety of Sars-Cov-2 vaccine in people with multiple sclerosis
BackgroundFor the past three years, the pandemic has had a major effect on global public health, mainly on those with underlying medical conditions,...
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Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from mitochondria into the cytosol. The released mtDNA is sensed by the...
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Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Several studies have reported compromised white matter integrity, and that some inflammatory mediators may underlie this functional dysconnectivity...
