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Anti-diabetic, anti-pancreatic lipase, and anti-protein glycation potential of Irvingia gabonensis stem bark extracts: in vitro and in silico studies
Diabetes mellitus is a chronic metabolic disorder that affects glucose, lipid, and protein metabolism. Targeting these metabolic derangements can...
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Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa
The new labdane-type diterpenoid, physaglutinic acid ( 1 ), was isolated from the hexane extract of Physalis glutinosa . This compound is the first...
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Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities
The development of novel analogues for the pancreatic lipase (PL) inhibitors and antioxidant candidates remains a significant research objective, as...
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Dipeptidyl Peptidase-IV Blockers Potently Inhibit Monoglyceride Lipase: Investigation By Docking Studies And In Vitro Bioassay
AbstractMonoglyceride lipase (MGL) is an important enzyme that plays a critical role in lipolysis and release of free fatty acids from...
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Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy
Synucleinopathy (Parkinson’s disease (PD); Lewy body dementia) disease-modifying treatments represent a huge unmet medical need. Although the...
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Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment
A series of coumarin-3-carboxamide analogues has been designed, synthesized and assessed for their ability to inhibit pancreatic lipase (PL). Amongst...
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Pancreatic Lipase (PL) Inhibitors from Medicinal Plants and Their Potential Applications in the Management of Obesity
Obesity is increasingly recognized as a global issue, and its prevalence is rising at an alarming rate around the globe. Obese people are more likely...
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Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial
Severe hypertriglyceridemia (sHTG) is an established risk factor for acute pancreatitis. Current therapeutic approaches for sHTG are often...
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Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
Acquisition and extinction of associative fear memories are critical for guiding adaptive behavioral responses to environmental threats, and...
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Bacterial Lipase Neutralized Toxicity of Lipopolysaccharide on Chicken Embryo Cardiac Tissue
It has been shown that near all organs, especially the cardiovascular system, are affected by bacterial lipopolysaccharide via the activation of...
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Monoacylglycerol Lipase Inhibition Prevents Short-Term Mitochondrial Dysfunction and Oxidative Damage in Rat Brain Synaptosomal/Mitochondrial Fractions and Cortical Slices: Role of Cannabinoid Receptors
Inhibition of enzymes responsible for endocannabinoid hydrolysis represents an invaluable emerging tool for the potential treatment of...
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BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells
BackgroundTriple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and...
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Immobilization of Candida rugosa lipase for resolution of racimic ibuprofen
AimDue to lipases’ regio-selectivity and ability to catalyze different reactions such as hydrolysis, esterification, and transesterification, the...
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Lipoprotein lipase hydrolysis products induce pro-inflammatory cytokine expression in triple-negative breast cancer cells
ObjectivesBreast cancer cell growth and proliferation requires lipids for energy production, cell membrane synthesis, or as signaling molecules....
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A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network
Monoacylglycerol lipase (MAGL) constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the...
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Engineering Lipase Enzyme Nano-powder Using Nano Spray Dryer BÜCHI B-90: Experimental and Factorial Design Approach for a Stable Biocatalyst Production
PurposeThe industrial applications of lipases are hampered by their sensitive nature to processing and storage conditions. In this context, this...
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Enzymatic Biosensors for Detection of Pancreatitis
Pancreatitis is an inflammation of the pancreas due to infection, alcohol abuse or trauma. The biomarkers for pancreatitis are α-amylase and lipase...
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Measuring Lipolytic Activity to Support Process Improvements to Manage Lipase-Mediated Polysorbate Degradation
PurposePolysorbates are critical stabilizers in biopharmaceutical protein formulations. However, they may degrade in drug substance (DS) or drug...
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Lipase is associated with deltamethrin resistance in Culex pipiens pallens
The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne...
