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A novel intradermal tattoo-based injection device enhances the immunogenicity of plasmid DNA vaccines
In recent years, tattooing technology has shown promising results toward evaluating vaccines in both animal models and humans. However, this...
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One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation
The incidence of rabies in Thailand reached its peak in 2018 with 18 human deaths. Preexposure prophylaxis (PrEP) vaccination is thus recommended for...
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Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial
Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in a pandemic. We assessed the...
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Immunogenicity and safety of an intradermal ChAdOx1 nCoV-19 boost in a healthy population
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Two doses of an inactivated SARS-CoV-2 vaccine (CoronaVac)...
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Preclinical safety assessment of the suction-assisted intradermal injection of the SARS-CoV-2 DNA vaccine candidate pGO-1002 in white rabbit
pGO-1002, a non-viral DNA vaccine that expresses both spike and ORF3a antigens of SARS-CoV-2, is undergoing phase 1 and phase 2a clinical trials in...
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Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges
We previously developed a temperature-sensitive, and NS1 gene deleted live attenuated influenza vaccine (DelNS1-LAIV) and demonstrated its potent...
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Nanoemulsion-based dissolving microneedle arrays for enhanced intradermal and transdermal delivery
The development of dissolving microneedles (DMN) is one of the advanced technologies in transdermal drug delivery systems, which precisely deliver...
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Effects of Intradermal Administration Volume Using a Hollow Microneedle on the Pharmacokinetics of Fluorescein Isothiocyanate Dextran (M.W. 4,000)
PurposeHollow microneedles (hMNs) have been gaining attention as a tool to enable the intradermal ( i.d. ) administration of pharmaceutical products....
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Progress in Intradermal and Transdermal Gene Therapy with Microneedles
Gene therapy is one of the most widely studied treatments and has the potential to treat a variety of intractable diseases. The skin's limited...
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Booster administration can make a difference in the antibody response to intradermal foot-and-mouth disease vaccination in cattle
Foot-and-mouth disease (FMD) is a highly contagious and economically important viral disease of cloven-hoofed animals. Routine vaccination is one of...
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Intradermal Vaccination with PLGA Nanoparticles via Dissolving Microneedles and Classical Injection Needles
PurposeA dissolving microneedle array (dMNA) is a vaccine delivery device with several advantages over conventional needles. By incorporating...
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Does an Intradermal Vaccination for Monkeypox Make Sense?
Mankind has recently had to deal a series of virus-mediated pandemics, resulting in extensive morbidity and mortality rates that have severely...
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Development of a diffusion-weighed mathematical model for intradermal drainage quantification
The quantitative assessment of lymphatic dermal clearance using NIR fluorescent tracers is particularly important for the early diagnosis of several...
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Penetration Enhancement Strategies for Intradermal Delivery of Cromolyn Sodium
This study aimed to explore the use of chemical and physical enhancement strategies for the intradermal delivery of cromolyn sodium (CS) for...
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Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy
PurposeWhilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population...
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A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution
PurposeHollow-type microneedles (hMNs) are a promising device for the effective administration of drugs into intradermal sites. Complete insertion of...
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Investigation of appropriate needle length considering skin thickness with the real injection posture for insulin injections in diabetic patients
BackgroundInsulin treatment is widely used not only for type 1 but also for type 2 diabetes patients. Insulin must be injected into the subcutaneous...
