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Detection Methods for H1N1 Virus
Influenza A virus H1N1, a respiratory virus transmitted via droplets and responsible for the global pandemic in 2009, belongs to the Orthomyxoviridae...
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Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus
BackgroundSwine influenza viruses (SIV), considered the “mixing vessels” of influenza viruses, posed a significant threat to global health systems...
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Augmented antiviral activity of chlorhexidine gluconate on herpes simplex virus type 1, H1N1 influenza A virus, and adenovirus in combination with salicylic acid
BackgroundThe excessive usage of chlorhexidine gluconate (CHG) as a broad-spectrum antimicrobial reagent can have a negative impact on the...
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Effects and mechanism of Qingke **chuan granules against influenza virus infection
Qingke **chuan granules (QPGs), which contain Houttuynia cordata Thunb, Fritillaria cirrhosa , fired licorice, and fired bitter almonds, among other...
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The PB1 gene from H9N2 avian influenza virus showed high compatibility and increased mutation rate after reassorting with a human H1N1 influenza virus
BackgroundReassortment between human and avian influenza viruses (AIV) may result in novel viruses with new characteristics that may threaten human...
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A mosaic influenza virus-like particles vaccine provides broad humoral and cellular immune responses against influenza A viruses
The development of a universal influenza vaccine to elicit broad immune responses is essential in reducing disease burden and pandemic impact. In...
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Evidence for the circulation of genotype 4 Eurasian avian-like lineage swine H1N1 influenza A viruses on Korean swine farms, obtained using a newly developed one-step multiplex RT-qPCR assay
Genotype 4 (G4) Eurasian avian-like lineage swine H1N1 influenza A viruses, which are reassortants containing sequences from the pandemic 2009 H1N1...
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Influenza A Virus (H1N1) Infection Induces Glycolysis to Facilitate Viral Replication
Viruses depend on host cellular metabolism to provide the energy and biosynthetic building blocks required for their replication. In this study, we...
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Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
BackgroundNon-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally....
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Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Current Influenza virus vaccines primarily induce antibody responses against variable epitopes in hemagglutinin (HA), necessitating frequent updates....
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Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation
Influenza is an acute viral respiratory illness with high morbidity rates worldwide. Excessive pulmonary inflammation is the main characteristic of...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Defining the balance between optimal immunity and immunopathology in influenza virus infection
Influenza A viruses remain a global threat to human health, with continued pandemic potential. In this Review, we discuss our current understanding...
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A novel film spray containing curcumin inhibits SARS-CoV-2 and influenza virus infection and enhances mucosal immunity
BackgroundInfection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza virus is still a major worldwide health concern....
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Influenza Virus Entry inhibitors
Influenza is a major challenge to health and the global economy. However, the increasing emergence of drug resistance during influenza pandemics...
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Intranasal administration of an aronia extract and carrageenan nanocomposite for the prevention of influenza A H1N1 virus infection
PurposeIn the present study, we describe an aronia extract (AE) and carrageenan (CGN) nanocomplex (ACNC) for intranasal administration that directly...
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miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4
Upregulation of ADAMTS-4 has been reported to have an important role in lung injury, and ADAMTS-4 expression is regulated by miR-126a-5p in abdominal...
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Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
BackgroundThe association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to...
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Green synthesis of MnO2 NPs using Arabic gum: assessing its potential antiviral activity against influenza A/H1N1
BackgroundThe antiviral properties of metal nanoparticles against various viruses, including those resistant to drugs, are currently a subject of...
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Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic...
