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The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy
The international American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system...
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Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer
Immunoscore ® is an in vitro diagnostic assay that is designed to predict the risk of relapse in patients with early-stage colon cancer, thus hel**...
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A Noninvasive Approach to Evaluate Tumor Immune Microenvironment and Predict Outcomes in Hepatocellular Carcinoma
It is widely recognized that tumor immune microenvironment (TIME) plays a crucial role in tumor progression, metastasis, and therapeutic response....
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Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma
Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell therapy approved for relapsed/refractory large B cell...
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APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis
BackgroundOvarian clear cell carcinoma (OCCC) is a challenging disease due to its intrinsic chemoresistance. Immunotherapy is an emerging treatment...
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An artificial intelligence method to assess the tumor microenvironment with treatment outcomes for gastric cancer patients after gastrectomy
BackgroundThe tumor microenvironment (TME) plays an important role in the occurrence and development of gastric cancer (GC) and is widely used to...
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Multistain deep learning for prediction of prognosis and therapy response in colorectal cancer
Although it has long been known that the immune cell composition has a strong prognostic and predictive value in colorectal cancer (CRC), scoring...
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The Role of Tumor Microenvironment in Colon Cancer
Colorectal cancer (CRC) is one of the most common causes of morbidity and mortality in both women and men. Given that CRC is an important health...
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Comprehensive Analysis for Predicting Prognoses and Immune Responses of m6A-Related lncRNAs in Women with Lung Adenocarcinoma
During the past decade, the average 5-year survival rate of patients with Lung adenocarcinoma (LUAD) has remained < 20%, although the targeted...
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The immune cell landscape of metastatic uveal melanoma correlates with overall survival
BackgroundUveal melanoma (UM) represents the most common primary intra-ocular malignancy in adults. Up to 50% of the patients develop distant...
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The tumour immune microenvironment in oesophageal cancer
Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-oesophageal reflux disease, obesity and tobacco use. Knowledge of...
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Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
BackgroundImmune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients respond to the...
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Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st–3rd, 2022—Naples, Italy)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune...
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Cancer Immunodiagnosis in Upper Gastrointestinal Cancers
The field of immuno-oncology has gained great interest. Novel immune-enhancing treatment modalities against cancer have been approved for some solid...
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Immune Checkpoint Blockade Response Biomarkers
Cancer immunotherapy based on immune checkpoint blockade (ICB) has demonstrated durable clinical benefit in patients with immunogenic tumors,...
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Role of Nano-immunotherapy in Colorectal Cancer: An Updated Review
Colorectal cancer (CRC) has become the leading cause of death among cancer patients in developed countries. Genetic and environmental factors, along...
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Implications of Tumor Immune Microenvironment and Molecular Markers for Cancer Immunotherapy
The tumor immune microenvironment (TIME) of solid tumors consists of heterogeneous cell types, including immune cells (T cells, B cells, plasma...
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Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment
BackgroundLung adenocarcinoma (LUAD) is a major subtype of lung cancer and closely associated with poor prognosis. N6-methyladenosine (m6A), one of...
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Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments
IntroductionGliomas, a type of brain neoplasm, are prevalent and often fatal. Molecular diagnostics have improved understanding, but treatment...
