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How to Build a Neuron
The neuron is simply another term for a brain cell. Cells, as we know, are the teeniest components of all living animals, at least in terms of a...
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A neuron model with nonlinear membranes
One-layer membrane separates the gradient field in and out of the cell, while some two-layer membranes filled with excitable media/material are...
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Synaptic Integration at Neuron-OPC Synapses
The synapses between neurons and oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS) have similar ultrastructures as...
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Hierarchies of description enable understanding of cognitive phenomena in terms of neuron activity
One objective of neuroscience is to understand a wide range of specific cognitive processes in terms of neuron activity. The huge amount of...
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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the substantia nigra pars compacta (SNpc) are central drivers of...
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Improving a cortical pyramidal neuron model’s classification performance on a real-world ecg dataset by extending inputs
Pyramidal neurons display a variety of active conductivities and complex morphologies that support nonlinear dendritic computation. Given growing...
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Memristive leaky integrate-and-fire neuron and learnable straight-through estimator in spiking neural networks
Compared to artificial neural networks (ANNs), spiking neural networks (SNNs) present a more biologically plausible model of neural system dynamics....
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Silencing Parkinson’s risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the...
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Single Neuron Modeling Identifies Potassium Channel Modulation as Potential Target for Repetitive Head Impacts
Traumatic brain injury (TBI) and repetitive head impacts can result in a wide range of neurological symptoms. Despite being the most common...
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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis
Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is achieved. We show here that Drosophila glia exhibit a...
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Long-term stability of single neuron activity in the motor system
How an established behavior is retained and consistently produced by a nervous system in constant flux remains a mystery. One possible solution to...
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Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions
We previously reported on two brothers who carry identical compound heterozygous PRKN mutations yet present with significantly different Parkinson’s...
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A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice
Exploring the relationship between neuronal dynamics and ethologically relevant behaviour involves recording neuronal-population activity using...
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Extreme multistability and phase synchronization in a heterogeneous bi-neuron Rulkov network with memristive electromagnetic induction
Memristive electromagnetic induction effect has been widely explored in bi-neuron network with homogeneous neurons, but rarely in bi-neuron network...
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A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans
Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of...
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Conventional and Spectral Karyoty** of Murine Cerebellar Granule Neuron Progenitors
Karyoty** remains an invaluable tool to researchers exploring the cause and consequence of genomic instability in biologic systems. It allows...
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Effects of Neuron Axons Degeneration in 2D Networks of Neuronal Oscillators
This chapter discusses the role of neuron axons degeneration in the synchronization properties of networks composed of biological neurons. The...
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nGauge: Integrated and Extensible Neuron Morphology Analysis in Python
The study of neuron morphology requires robust and comprehensive methods to quantify the differences between neurons of different subtypes and animal...
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Motor Neuron Disease: Amyotrophic Lateral Sclerosis
In this chapter, we will review the epidemiology, clinical phenotype, genetics, causes, and management of amyotrophic lateral sclerosis (ALS). ALS is...