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CGRP inhibits human Langerhans cells infection with HSV by differentially modulating specific HSV-1 and HSV-2 entry mechanisms
Herpes simplex virus (HSV) is widespread globally, with both HSV-1 and HSV-2 responsible for genital herpes. During sexual transmission, HSV targets...
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Computational Integration of HSV-1 Multi-omics Data
Functional genomics techniques based on next-generation sequencing provide new avenues for studying host responses to viral infections at multiple...
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Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas
Pathophysiologic inflammation, e.g., from HSV-1 viral infection, can cause tissue destruction resulting in ulceration, perforation, and ultimately...
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Generation of High-Titer Defective HSV-1 Amplicon Vectors
Strategies for gene delivery into neurons, either to study the molecular biology of brain function or for gene therapy, must utilize vectors that...
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Intimate Relationship Between Stress and Human Alpha-Herpes Virus 1 (HSV-1) Reactivation from Latency
Purpose of ReviewNumerous studies concluded stress (acute, episodic acute, or chronic) increases the incidence of human alpha-herpes virus 1 (HSV-1)...
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Seropositivity and reactivations of HSV-1, but not of HSV-2 nor VZV, associate with altered blood–brain barrier, beta amyloid, and tau proteins in people living with HIV
Among 128 adult people living with HIV and no neurological conditions confounding the cerebrospinal fluid results, the presence of HSV-1 chronic...
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Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the viral envelope
Herpes simplex virus type 1 (HSV-1) is a widely disseminated virus that establishes latency in the brain and causes occasional but fatal herpes...
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The Analysis of Herpes Simplex Virus Type 1 (HSV-1)-Encoded MicroRNAs Targets: A Likely Relationship of Alzheimer's Disease and HSV-1 Infection
Alzheimer's disease (AD), the most frequently diagnosed dementia, is a senile neurodegenerative disorder characterized by amnesia and cognitive...
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Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1
BackgroundIn 2015, herpes simplex virus 1 (HSV-1)-derived talimogene laherparepvec (T-VEC) was the first oncolytic virus approved by the US Food and...
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HSV-1 latency-associated transcript miR-H3 and miR-H4 target STXBP1 and GABBR2 genes
During latent infection, the HSV-1 virus generates only a single transcript, LAT, which encodes six miRNAs. The GABAergic pathway signaling system is...
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Cell type-specific response of colon cancer tumor cell lines to oncolytic HSV-1 virotherapy in hypoxia
BackgroundNovel strategies are required since the hypoxic tumor microenvironment is one of the important impediments for conventional cancer therapy....
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Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses
BackgroundHerpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1...
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Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
BackgroundMicroglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes...
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How an increase in the copy number of HSV-1 during latency can cause Alzheimer’s disease: the viral and cellular dynamics according to the microcompetition model
Numerous studies observed a link between the herpes smplex virus-1 (HSV-1) and Alzheimer’s disease. However, the exact viral and cellular dynamics...
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Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes
BackgroundHerpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and...
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Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity
A majority of the world’s population is infected with HSV-1, highlighting the need for vaccines that are effective in HSV-1-seropositive hosts. We...
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Antitumor effects of IL-12 and GM-CSF co-expressed in an engineered oncolytic HSV-1
Oncolytic viruses selectively replicate and destroy cancer cells while sparing normal cells, prompting their recognition as promising antitumor...
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HSV-1 H129-Derived Anterograde Neural Circuit Tracers: Improvements, Production, and Applications
Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed...
