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Association of Genetic Polymorphisms in Long Noncoding RNA HOTTIP with Risk of Idiopathic Recurrent Spontaneous Abortion
The clustered homeobox gene family known as the Hox family plays a fundamental role in the morphogenesis of the vertebrate’s embryo. A long noncoding...
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LncRNA HOTTIP Knockdown Attenuates Acute Myocardial Infarction via Regulating miR-92a-2/c-Met Axis
Increasing investigations have focused on long non-coding RNAs (lncRNAs) in various human diseases, including acute myocardial infarction (AMI)....
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WDR5-HOTTIP Histone Modifying Complex Regulates Neural Migration and Dendrite Polarity of Pyramidal Neurons via Reelin Signaling
WD-repeat domain 5 (WDR5), a core component of histone methyltransferase complexes, is associated with Kabuki syndrome and Kleefstra syndrome that...
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Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils
BackgroundLong non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP), has been demonstrated to be a vital biomarker when evaluating the...
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CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein
BackgroundCircular RNAs (circRNAs) play important roles in many biological processes. However, the detailed mechanism underlying the critical roles...
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Clinical Utility of Noncoding RNAs as Systemic Biomarkers in Animal Models
Noncoding RNAs are the RNAs that do not encode for proteins, yet play a vital role in various cellular processes. Compelling cancer research evidence...
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Emerging Role of Long Noncoding RNAs in Regulating Inflammasome-Mediated Neurodegeneration in Parkinson’s Disease
Parkinson’s disease (PD) is one of the complex neurodegenerative disorders, primarily characterized by motor deficits, including bradykinesia,...
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Long Noncoding RNA Acting as Therapeutic Target for Oxidative Stress-Induced Pancreatic Cancer
Pancreatic cancer (PanCa) is a systemic disease with both locally advanced and malignant neoplastic phenotypes and has a poor prognosis. Among all...
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Regulation of HOX gene expression in AML
As key developmental regulators, HOX cluster genes have varied and context-specific roles in normal and malignant hematopoiesis. A complex...
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Long Noncoding RNA Acting as Therapeutic Target for Oxidative Stress-Induced Pancreatic Cancer
Pancreatic cancer (PanCa) is a systemic disease with both locally advanced and malignant neoplastic phenotypes and has a poor prognosis. Among all...
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Correction to: Long non-coding RNA HOTTIP enhances IL-6 expression to potentiate immune escape of ovarian cancer cells by upregulating the expression of PD-L1 in neutrophils
An amendment to this paper has been published and can be accessed via the original article.
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Clinical Utility of Noncoding RNAs as Systemic Biomarkers in Animal Models
Noncoding RNAs are the RNAs that do not encode for proteins, yet play a vital role in various cellular processes. Compelling cancer research evidence...
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Molecular mechanisms of microRNA-216a during tumor progression
MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA...
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Long Non-Coding RNAs and microRNAs Groups in the Regulation of Expression Level of a Number of Tumor-Associated Genes in Ovarian Cancer
The search for interacting long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs of protein-coding genes through the mechanism of competing...
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MethScore as a new comprehensive DNA methylation-based value refining the prognosis in acute myeloid leukemia
BackgroundChanges in DNA methylation are common events in the pathogenesis of acute myeloid leukemia (AML) and have been repeatedly reported as...
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A Critical Approach in the Analysis of lncRNA Characteristics for Cancer Therapy
Long noncoding RNAs (lncRNAs) play a major role in cancer due to mutations in the protein-coding genes. There is a strong relationship between the...
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The chromatin-associated RNAs in gene regulation and cancer
Eukaryotic genomes are prevalently transcribed into many types of RNAs that translate into proteins or execute gene regulatory functions. Many RNAs...
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Exosomal long noncoding RNA HOTTIP as potential novel diagnostic and prognostic biomarker test for gastric cancer
Long noncoding RNA HOTTIP plays important roles in the generation and progression of human cancers. Exosomes participate in cellular communication by...
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Molecular insights into regulatory RNAs in the cellular machinery
It is apparent that various functional units within the cellular machinery are derived from RNAs. The evolution of sequencing techniques has resulted...
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Functional interplay between long non-coding RNAs and Breast CSCs
Breast cancer (BC) represents aggressive cancer affecting most women’s lives globally. Metastasis and recurrence are the two most common factors in a...
