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Antibodies to Glycolipids in Guillain-Barré Syndrome, Miller Fisher Syndrome and Related Autoimmune Neurological Diseases
Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) are acute immune-mediated neuropathies, often preceded by an infection....
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Aryl-functionalised α,α′-Trehalose 6,6′-Glycolipid Induces Mincle-independent Pyroptotic Cell Death
α,α′-Trehalose 6,6′-glycolipids have long been known for their immunostimulatory properties. The adjuvanticity of α,α′-trehalose 6,6′-glycolipids is...
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Opposite Functions of Mono- and Disialylated Glycosphingo-Lipids on the Membrane of Cancer Cells
Since cDNAs of glycosyltransferase genes were isolated, and become applicable for genetic engineering of glycosylation patterns, biological functions...
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Role of Gltp in Maturation of Oligodendrocytes Under the Regulation of Nkx2.2
Myelin, a lipid-enriched multi-layer membrane structure, allows for rapid long-distance saltatory conduction of neuronal impulses. Although...
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Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates
This chapter provides an overview of structures and functions of complex carbohydrates (commonly called glycans) that are covalently linked to...
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Immune Recognition of Pathogen-Derived Glycolipids Through Mincle
Mincle (macrophage inducible C-type lectin, Clec4e, Clecsf9) was originally identified as a member of the C-type lectin receptor family in 1999....
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Identification of the Lipid Antigens Recognized by rHIgM22, a Remyelination-Promoting Antibody
Failure of the immune system to discriminate myelin components from foreign antigens plays a critical role in the pathophysiology of multiple...
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Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment
Gangliosides are sialylated glycolipids, mainly present at the cell surface membrane, involved in a variety of cellular signaling events. During...
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Basic Knowledge of Glycobiology
Free carbohydrates are divided into monosaccharides, oligosaccharides, and polysaccharides. This chapter gives the chemical structures of the most...
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Carbohydrate Analysis of Glycoconjugates
For studies of glycan structure/function relationships of glycoconjugates, a detailed characterization of the carbohydrate moiety is a prerequisite....
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Analysis of Sialic Acids
Sialic acids are a family of acidic sugars, in particular, of glycoproteins and glycolipids, where they have multiple functions in determining the...
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Functional Impairment of the Nervous System with Glycolipid Deficiencies
Patients with nervous system disorders suffer from impaired cognitive, sensory and motor functions that greatly inconvenience their daily life and...
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Characterization of Human Parainfluenza Virus Receptor Using Terminal Sialic Acid Linkage-Modified Cells
Human parainfluenza virus type 1 (hPIV1) and type 3 (hPIV3) are respiratory pathogen viruses that bind to terminal sialic acids of glycoconjugates on...
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Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins
Many membrane-resident and secreted proteins, including growth factors and their receptors are N-glycosylated. The initial N-glycan structure is...
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Synthesis of O-Linked Glycoconjugates in the Nervous System
Glycoproteins carrying O-linked N-acetylgalactosamine, N-acetylglucosamine, mannose, fucose, glucose, and xylose are found in the nervous system....
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Effects of Monoacyltrehalose Fraction of Rhodococcus Biosurfactant on the Innate and Adaptive Immunity Parameters In Vivo
The biosurfactant monoacyltrehalose fraction isolated from Rhodococcus ruber IEGM 231 actinobacterium suppresses antibody production, bactericidal...
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Gangliosides and Cell Surface Ganglioside Metabolic Enzymes in the Nervous System
Gangliosides are a large group of complex lipids found predominantly in the outer layer of the plasma membrane of cells, particularly abundant in...
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Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR
Carbohydrate chains play critical roles in cellular recognition and subsequent signal transduction in the nervous system. Furthermore, gangliosides...
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