Search
Search Results
-
-
-
-
Tenofovir disoproxil fumarate mediates neuronal injury by inducing neurotoxicity
PurposeHighly active antiretroviral therapy (HAART) is an accepted treatment option for patients with virus infection. Mounting evidence indicated...
-
Cancer Prevalence in Children with Inborn Errors of Immunity: Report from a Single Institution
BackgroundInborn Errors of Immunity (IEI) comprise several genetic anomalies that affect different components of the innate and adaptive responses,...
-
Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Despite routine analysis of a large panel of genes, pathogenic variants are only detected in approximately 20% of families with hereditary breast...
-
Impact of Chemotherapeutic Drugs Towards Oxidative Stress and Associated Multi-organ Physiological Responses
Cancer represents a large burden on the global healthcare system, and many cancer chemotherapeutics are included on the World Health Organization’s...
-
Impact of Chemotherapeutic Drugs Towards Oxidative Stress and Associated Multi-organ Physiological Responses
Cancer represents a large burden on the global healthcare system, and many cancer chemotherapeutics are included on the World Health Organization’s...
-
Fanconi anemia pathway and its relationship with cancer
Fanconi Anemia (FA) is a rare inherited hematological disease, caused by mutations in genes involved in the DNA interstrand crosslink (ICL) repair....
-
Germline mutations in prostate cancer: a systematic review of the evidence for personalized medicine
BackgroundThe goal of precision medicine in prostate cancer (PCa) is to individualize the treatment according to the patient’s germline mutation...
-
Acute myeloid leukemia: from NGS, through scRNA-seq, to CAR-T. dissect cancer heterogeneity and tailor the treatment
Acute myeloid leukemia (AML) is a malignant blood cancer with marked cellular heterogeneity due to altered maturation and differentiation of myeloid...
-
An overview on tumor treating fields (TTFields) technology as a new potential subsidiary biophysical treatment for COVID-19
COVID-19 pandemic situation has affected millions of people with tens of thousands of deaths worldwide. Despite all efforts for finding drugs or...
-
Fanconi anemia: current insights regarding epidemiology, cancer, and DNA repair
Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well as a predisposition to malignancies including leukemia and...
-
Antiviral Drugs
Viruses are obligate intracellular organisms. They require host cell for replication process. Different classes of drugs are available for targeting...
-
Advanced Therapy Medicinal Products: Clinical, Non-clinical, and Quality Considerations
Cell therapy, tissue engineering, and gene therapy products, together called “advanced therapy medicinal products” (ATMPs), represent a heterogeneous...
-
Human Umbilical Cord Blood Serum/Plasma: Cytokine Profile and Prospective Application in Regenerative Medicine
The concentrations of cytokines and growth factors in human umbilical cord blood serum and plasma samples were measured by multiplex analysis. It was...
-
-
Pharmacogenetic determinants of kidney-associated urinary and serum abnormalities in antiretroviral-treated HIV-positive patients
Tenofovir disoproxyl fumarate (TDF) has been associated with renal tubular abnormalities, phosphaturia and proteinuria (retinol binding protein, RBP,...
-
Genetics-related service and information needs of childhood cancer survivors and parents: a mixed-methods study
Genetics in paediatric oncology is becoming increasingly important in diagnostics, treatment and follow-up care. Genetic testing may offer a...
-
Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are clonal hematopoietic stem cell (HSC) malignancies that represent a heterogeneous group characterized by...