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FGFR4-driven plasticity in breast cancer progression and resistance to therapy
Breast cancer (BCa) is a complex and heterogeneous disease, with different intrinsic molecular subtypes that have distinct clinical outcomes and...
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Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
BackgroundRhabdomyosarcoma (RMS) is a paediatric cancer driven either by fusion proteins (e.g., PAX3-FOXO1) or by mutations in key signalling...
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Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing
BackgroundDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets....
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FGFR4 and EZH2 inhibitors synergistically induce hepatocellular carcinoma apoptosis via repressing YAP signaling
BackgroundHepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide, but current treatment options remain limited and...
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The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression
BackgroundRNA N6-Methyladenosine (m6A) modification is implicated in the progression of human cancers including cholangiocarcinoma (CCA). METTL16 is...
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CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
BackgroundRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic,...
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The anti-tumor effects of AZD4547 on ovarian cancer cells: differential responses based on c-Met and FGF19/FGFR4 expression
BackgroundThe FGF/FGFR signaling pathway plays a critical role in human cancers. We analyzed the anti-tumor effect of AZD4547, an inhibitor targeting...
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Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment
BackgroundTAS-102 (Lonsurf ® ) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine...
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Src is essential for the endosomal delivery of the FGFR4 signaling complex in hepatocellular carcinoma
BackgroundHepatocytes usually express fibroblast growth factor receptor 4 (FGFR4), but not its ligand, fibroblast growth factor 19 (FGF19). A subtype...
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FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis
BackgroundThere is no consensus about the effective dosages of melatonin in cancer management, thus, it is imperative to fully understand the...
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FGFR4 promotes nuclear localization of GABP to inhibit cell apoptosis in uterine leiomyosarcoma
Fibroblast growth factor receptor 4 (FGFR4) has been indicated as a potential “oncogene” in various types of cancer. However, the effects and...
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Development of nomogram based on immune-related gene FGFR4 for advanced non-small cell lung cancer patients with sensitivity to immune checkpoint inhibitors
IntroductionImmune checkpoint inhibitors (ICIs) have become a frontier in the field of clinical technology for advanced non-small cell lung cancer...
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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
BackgroundChimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of...
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The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer
PurposeThe gastric adenocarcinoma (GC) represents the third cause of cancer-related mortality worldwide, and available therapeutic options remain...
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Fibroblast growth factor receptor 4 deficiency in macrophages aggravates experimental colitis by promoting M1-polarization
Objective and designCompelling evidence indicates that dysregulated macrophages may play a key role in driving inflammation in inflammatory bowel...
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Fibroblast growth factor receptor type 4 as a potential therapeutic target in clear cell renal cell carcinoma
BackgroundSeveral clear cell renal cell carcinoma (ccRCC) cases harbour fibroblast growth factor receptor 4 ( FGFR4 ) gene copy number (CN) gains. In...
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Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness
Glioblastoma (GBM) is characterized by a particularly invasive phenotype, supported by oncogenic signals from the fibroblast growth factor (FGF)/ FGF...
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Whole-exome sequencing reveals candidate high-risk susceptibility genes for endometriosis
BackgroundEndometriosis is a common, chronic disease among fertile-aged women. Disease course may be highly invasive, requiring extensive surgery....
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A first-in-human phase 1/2 study of FGF401 and combination of FGF401 with spartalizumab in patients with hepatocellular carcinoma or biomarker-selected solid tumors
BackgroundDeregulation of FGF19-FGFR4 signaling is found in several cancers, including hepatocellular carcinoma (HCC), nominating it for therapeutic...
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Malignant peritoneal mesotheliomas of rats induced by multiwalled carbon nanotubes and amosite asbestos: transcriptome and epigenetic profiles
BackgroundMalignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a...
