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Activation of Ventral Tegmental Area Dopaminergic Neurons Projecting to the Parabrachial Nucleus Promotes Emergence from Propofol Anesthesia in Male Rats
Since the clinical introduction of general anesthesia, its underlying mechanisms have not been fully elucidated. The ventral tegmental area (VTA) and...
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Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is widely used in computer-aided drug...
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Evolutionary trajectory of SARS-CoV-2 genome shifts during widespread vaccination and emergence of Omicron variant
Understanding the adaptation of SARS-CoV-2 is critical for the development of effective treatments against this exceptionally successful human...
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Emergence of an Abnormal Personality
There are ten types of personality disorders (PDs). The overall prevalence of these in the United States of America is highest for...
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The Emergence of Mpox: Epidemiology and Current Therapeutic Options
The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an...
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Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus
The emergence of consciousness from anesthesia, once assumed to be a passive process, is now considered as an active and controllable process. In the...
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The Emergence and Widespread Circulation of Enteric Viruses Throughout the COVID-19 Pandemic: A Wastewater-Based Evidence
Growing evidence shed light on the importance of wastewater-based epidemiology (WBE) during the pandemic, when the patients rarely visited the...
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A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization...
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Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic?
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy...
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Factors Contributing to the Emergence of Viral Diseases
Viruses evolve and adapt to conform to brand new hosts and challenges, be it environmental or manmade. These obstacles can either prevent their...
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Emergence dynamics of adult Culicoides biting midges at two farms in south-east England
BackgroundCulicoides biting midges (Diptera: Ceratopogonidae) are biological vectors of livestock arboviruses that cause diseases with significant...
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Emergence of sense of body ownership but not agency during virtual tool-use training is associated with an altered body schema
In this study we examined if training with a virtual tool in augmented reality (AR) affects the emergence of ownership and agency over the tool and...
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The global risk of infectious disease emergence from giant land snail invasion and pet trade
BackgroundPathogen outbreaks mostly originate from animals, but some species are more likely to trigger epidemics. The giant land snail ( Lissachatina...
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Increase in rotavirus prevalence with the emergence of genotype G9P[8] in replacement of genotype G12P[6] in Sabah, Malaysia
Rotaviruses are major causative agents of acute diarrhea in children under 5 years of age in Malaysia. However, a rotavirus vaccine has not been...
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Emergence of an ST1934:KL121 hypervirulent Klebsiella pneumoniae carrying a novel virulence-resistance hybrid plasmid with chromosomal integration of ICEKp1
To identify the phenotypic and genomic characteristics of K. pneumoniae KP43 from bloodstream infection. KP43 was resistant to ticarcillin and...
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Dopaminergic Neurons in the Ventral Tegmental–Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia
Dopaminergic neurons in the ventral tegmental area (VTA) play an important role in cognition, emergence from anesthesia, reward, and aversion, and...
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Emergence of extensive drug resistance and high prevalence of multidrug resistance among clinical Proteus mirabilis isolates in Egypt
BackgroundProteus mirabilis is an opportunistic pathogen that has been held responsible for numerous nosocomial and community-acquired infections...
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Emergence of CWD strains
Chronic wasting disease (CWD) strains present a novel challenge to defining and mitigating this contagious prion disease of deer, elk, moose, and...
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The emergence of molecular systems neuroscience
Systems neuroscience is focused on how ensemble properties in the brain, such as the activity of neuronal circuits, gives rise to internal brain...
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The emergence of RAS mutations in patients with RAS wild-type mCRC receiving cetuximab as first-line treatment: a noninterventional, uncontrolled multicenter study
BackgroundPatients treated with anti-epidermal growth factor receptor (anti-EGFR) will ultimately develop acquired resistance promoted by clonal...
