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The fMRI correlates of visuo-spatial abilities: sex differences and gender dysphoria
The contribution of brain regions to visuospatial abilities according to sex differences and gender identity is inconsistently described. One...
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A community-based study of demographics, medical and psychiatric conditions, and gender dysphoria/incongruence treatment in transgender/gender diverse individuals
BackgroundCurrent understanding about health care in the gender diverse population is limited by the lack of community-based, longitudinal data,...
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Sexual Differentiation of the Human Brain in Relation to Gender-Identity, Sexual Orientation, and Neuropsychiatric Disorders
Gender identity (an individual’s perception of being male or female) and sexual orientation (heterosexuality, homosexuality, or bisexuality) are...
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The Associations Between Neuropsychiatric Symptoms and Cognition in People with Dementia: A Systematic Review and Meta-Analysis
Most people with dementia experience neuropsychiatric symptoms (NPS), including anxiety, depression or disinhibition. There is growing interest in...
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Sexual Differentiation of the Human Brain in Relation to Gender-Identity, Sexual Orientation, and Neuropsychiatric Disorders
Gender identity (an individual’s perception of being male or female) and sexual orientation (heterosexuality, homosexuality, or bisexuality) are...
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Network analysis of neuropsychiatric symptoms in Alzheimer’s disease
BackgroundNeuropsychiatric symptoms due to Alzheimer’s disease (AD) and mild cognitive impairment (MCI) can decrease quality of life for patients and...
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Neuroimaging gender dysphoria: a novel psychobiological model
Gender identity development is complex and involves several key processes. Transgender people experience incongruence between their biological and...
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Replacement Hormone Therapy for Gender Dysphoria and Congenital Sexual Anomalies
What is it about sexuality that makes it such a burning matter since the dawn of mankind? Much was lost of humankind heritage because of society’s...
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An observational prospective study based on a large cohort of HIV-negative neurosyphilis patients with particular reference to the Jarisch-Herxheimer reaction
PurposeThe purpose of this study is to outline a complete picture of Jarisch-Herxheimer reaction (JHR) in the central nervous system among...
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Persisting neuropsychiatric symptoms, Alzheimer’s disease, and cerebrospinal fluid cortisol and dehydroepiandrosterone sulfate
IntroductionNeuropsychiatric symptoms are important treatment targets in the management of dementia and can be present at very early clinical stages...
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Transgender and gender-diverse (TGD) individuals’ perspectives on research seeking genetic variants associated with TGD identities: a qualitative study
Recent genetic research has explored how genetic variants may contribute to gender dysphoria and transgender and gender-diverse (TGD) identities....
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Influence of Sex on the Effects of Nicotine and Other Drugs of Abuse on Intracranial Self-Stimulation
Drug abuse is one of the leading causes of loss of productivity, disease, and early death in the world. People typically start experimenting with...
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Plasma gamma-aminobutyric acid (GABA) levels and posttraumatic stress disorder symptoms in trauma-exposed women: a preliminary report
RationaleAberrations in the stress response are associated with posttraumatic stress disorder (PTSD) symptom development, maintenance, and severity....
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Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
RationaleMedications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities that drive opioid...
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Pharmacokinetics and safety of a new generic lurasidone: a phase I bioequivalence study in healthy Chinese subjects
Latuda ® is a novel antipsychotic drug for schizophrenia and bipolar depression. A bioequivalence trial was performed to investigate the...
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Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder
Dynorphin (DYN) is an endogenous neurosecretory peptide which exerts its activity by binding to the family of G protein-coupled receptors, namely the...
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Contingent administration of typical and biased kappa opioid agonists reduces cocaine and oxycodone choice in a drug vs. food choice procedure in male rhesus monkeys
RationaleCombinations of mu and kappa-opioid receptor (KOR) agonists have been proposed as analgesic formulations with reduced abuse potential. The...
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Cancer surveillance for transgender and gender diverse patients with Lynch syndrome: a practice resource of the Collaborative Group of the Americas on Inherited Gastrointestinal Cancer
Transgender and gender diverse (TGD) populations with hereditary cancer syndromes face unique obstacles to identifying and obtaining appropriate...
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