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Influence of Sex on the Effects of Nicotine and Other Drugs of Abuse on Intracranial Self-Stimulation

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Methods for Preclinical Research in Addiction

Part of the book series: Neuromethods ((NM,volume 174))

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Abstract

Drug abuse is one of the leading causes of loss of productivity, disease, and early death in the world. People typically start experimenting with drugs of abuse during adolescence, and about 20% of people who use drugs develop a substance abuse disorder. In general, drug use is more common in men than in women. However, when women use drugs, they are just as likely as men to develop a substance use disorder. Drugs of abuse induce euphoria, and the rewarding properties of drugs play an essential role in the early stages of drug use. After the development of dependence, cessation of drug use leads to somatic and affective withdrawal signs, which contributes to the maintenance of drug use. The intracranial self-stimulation (ICSS) method can be used to measure the acute rewarding properties of drugs and the dysphoria associated with drug withdrawal. One of the main advantages of the ICSS method is that it provides a quantitative measure of the rewarding aspects of drug use and the aversive aspects of withdrawal. The ICSS method can be used to identify sex differences in the rewarding and aversive aspects of drug use.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of Florida, Gainesville, FL, USA

    Ranjithkumar Chellian, Ryann Wilson & Azin Behnood-Rod

  2. Department of Psychiatry, Center for Addiction Research and Education, University of Florida, Gainesville, FL, USA

    Adriaan W. Bruijnzeel

Authors
  1. Ranjithkumar Chellian
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  2. Ryann Wilson
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  3. Azin Behnood-Rod
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  4. Adriaan W. Bruijnzeel
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Corresponding author

Correspondence to Adriaan W. Bruijnzeel .

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Editors and Affiliations

  1. Unit of Research “Neurobehavioral Mechanisms and Endophenotypes of Addictive Behavior” Department of Psychobiology, Faculty of Psychology, University of Valencia, Valencia, Spain

    María A. Aguilar

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Chellian, R., Wilson, R., Behnood-Rod, A., Bruijnzeel, A.W. (2022). Influence of Sex on the Effects of Nicotine and Other Drugs of Abuse on Intracranial Self-Stimulation. In: Aguilar, M.A. (eds) Methods for Preclinical Research in Addiction. Neuromethods, vol 174. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1748-9_1

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  • DOI: https://doi.org/10.1007/978-1-0716-1748-9_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1747-2

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