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Dissociated face- and word-selective intracerebral responses in the human ventral occipito-temporal cortex
The extent to which faces and written words share neural circuitry in the human brain is actively debated. Here, we compare face-selective and...
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Rapid single-cell physical phenoty** of mechanically dissociated tissue biopsies
During surgery, rapid and accurate histopathological diagnosis is essential for clinical decision making. Yet the prevalent method of intra-operative...
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Primary Culture of Dissociated Neurons from the Embryonic Cerebral Cortex
Primary neuronal culture is a valuable in vitro model for analyzing the molecular mechanisms underlying the development and function of neural...
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Dissociated cerebellar contributions to feedforward gait adaptation
The cerebellum is important for motor adaptation. Lesions to the vestibulo-cerebellum selectively cause gait ataxia. Here we investigate how such...
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Non-symbolic and symbolic number lines are dissociated
People use mental number lines for both symbolic numerals and numerosity, but little is known about how these two mental number lines are related....
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TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens
BackgroundKey to the advancement of the field of bioelectronic medicine is the identification of novel pathways of neural regulation of immune...
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Brain Multiparametric Responses to Hyperbaric Hyperoxia
To elucidate the mechanism of brain toxicity developed under hyperbaric oxygenation (HBO), a multiparameter monitoring approach was adopted. ln the...
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SREBP signaling is essential for effective B cell responses
Our previous study using systems vaccinology identified an association between the sterol regulatory binding protein (SREBP) pathway and humoral...
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for...
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mRNA-LNP vaccination-based immunotherapy augments CD8+ T cell responses against HPV-positive oropharyngeal cancer
Although mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how...
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Multifocal organoids reveal clonal associations between synchronous intestinal tumors with pervasive heterogeneous drug responses
Multifocal colorectal cancer (CRC) comprises both clonally independent primary tumors caused by inherited predisposition and clonally related tumors...
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Blockade of TGF-β and PD-L1 by bintrafusp alfa promotes survival in preclinical ovarian cancer models by promoting T effector and NK cell responses
BackgroundFailure of immunotherapy in high-grade serous ovarian cancer (HGSC) may be due to high levels of transforming growth factor-β (TGF-β) in...
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Transient Receptor Potential Ankyrin-1-expressing vagus nerve fibers mediate IL-1β induced hypothermia and reflex anti-inflammatory responses
BackgroundInflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β)...
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Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine
Abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for Alzheimer’s disease and additional...
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XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner
BackgroundDifferences in male vs. female immune responses are well-documented and have significant clinical implications. While the immunomodulatory...
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Dissociated responses at initial computed tomography evaluation is a good prognostic factor in non-small cell lung cancer patients treated with anti-programmed cell death-1/ligand 1 inhibitors
BackgroundDissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The...
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Attenuated Dengue virus PV001-DV induces oncolytic tumor cell death and potent immune responses
BackgroundViral therapies developed for cancer treatment have classically prioritized direct oncolytic effects over their immune activating...
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rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
BackgroundAutologous tumor cell-based vaccines (ATVs) aim to prevent and treat tumor metastasis by activating patient-specific tumor antigens to...
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Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems
Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology....
