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Screening mammography frequency following dense breast notification among a predominantly Hispanic/Latina screening cohort
PurposeNationally legislated dense breast notification (DBN) informs women of their breast density (BD) and the impact of BD on breast cancer risk...
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Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women
PurposeOne major risk factor for breast cancer is high mammographic density. It has been estimated that dense breast tissue contributes to ~ 30% of...
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An observational study of dose dense chemotherapy with lipegfilgrastim support in early breast cancer
PurposeBreast cancer is one of the most prevalent malignant diseases in women. The development of dose dense chemotherapy regimens has improved...
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Dose dense doxorubicin plus cyclophosphamide in a modified KEYNOTE522 regimen for triple negative breast cancer
The KEYNOTE-522 (KN522) regimen for neoadjuvant treatment of triple negative breast cancer (TNBC) utilized q3week dosing for doxorubicin plus...
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Breast density knowledge and willingness to delay treatment for pre-operative breast cancer imaging among women with a personal history of breast cancer
BackgroundFollowing a breast cancer diagnosis, it is uncertain whether women’s breast density knowledge influences their willingness to undergo...
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Effect of testosterone therapy on breast tissue composition and mammographic breast density in trans masculine individuals
BackgroundThe effect of gender-affirming testosterone therapy (TT) on breast cancer risk is unclear. This study investigated the association between...
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Immunotherapy in Breast Cancer
Breast cancer affects 12% of women worldwide. Although advances in systemic, surgical, and radiation therapy approaches will cure a large proportion...
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Associations of stem cell markers CD44, CD24 and ALDH1A1 with mammographic breast density in women with benign breast biopsies
BackgroundWe examined associations of CD44, CD24 and ALDH1A1 breast stem cell markers with mammographic breast density (MBD), a well-established...
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Breast cancer worry, uncertainty, and perceived risk following breast density notification in a longitudinal mammography screening cohort
BackgroundDense breast notification (DBN) legislation aims to increase a woman’s awareness of her personal breast density and the implications of...
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Impact of breast density on diagnostic accuracy in digital breast tomosynthesis versus digital mammography: results from a European screening trial
BackgroundThe diagnostic accuracy of digital breast tomosynthesis (DBT) and digital mammography (DM) in breast cancer screening may vary per breast...
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Breast stiffness, a risk factor for cancer and the role of radiology for diagnosis
Over the last five decades, breast density has been associated with increased risk of develo** breast cancer. Mammographically dense breasts are...
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Screening mammography performance according to breast density: a comparison between radiologists versus standalone intelligence detection
BackgroundArtificial intelligence (AI) algorithms for the independent assessment of screening mammograms have not been well established in a large...
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Alternative methods to measure breast density in younger women
BackgroundBreast density is a strong and potentially modifiable breast cancer risk factor. Almost everything we know about breast density has been...
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Composite risk and benefit from adjuvant dose-dense chemotherapy in hormone receptor-positive breast cancer
The GIM2 phase III trial demonstrated the benefit of dose-dense chemotherapy in node-positive early breast cancer (eBC). To better define the...
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Association of area- and volumetric-mammographic density and breast cancer risk in women of Asian descent: a case control study
BackgroundMammographic density (MD) has been shown to be a strong and independent risk factor for breast cancer in women of European and Asian...
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Impact of dose-dense neoadjuvant chemotherapy on pathologic response and survival for HER2-positive breast cancer patients who receive trastuzumab
To compare outcomes in patients with human epidermal growth factor receptor-2 (HER2)-positive breast cancer who received either dose-dense...
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Epigenetics of Breast Cancer
Epigenetic modulations of gene expression, post-transcriptional silencing of messenger RNA (mRNA), and post-translational modifications of protein...
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Untargeted serum metabolomic profiles and breast density in young women
Purpose of the studyBreast density is an established risk factor for breast cancer. However, little is known about metabolic influences on breast...
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Causal relationships between breast cancer risk factors based on mammographic features
BackgroundMammogram risk scores based on texture and density defined by different brightness thresholds are associated with breast cancer risk...
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Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease
IntroductionBenign breast disease (BBD) and high mammographic breast density (MBD) are prevalent and independent risk factors for invasive breast...