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Dual host-pathogen small RNA sequencing during wheat stem rust infection
ObjectivesRNA sequencing of two organisms in a symbiotic interaction can yield insights that are not found in samples from each organism alone. We...
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Distribution of Small RNAs Along Transposable Elements in Vitis vinifera During Somatic Embryogenesis
Metaviridae is a family of reverse-transcribing viruses, closely related to retroviruses; they exist within their host’s DNA as transposable...
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Protein Degradome of Spinal Cord Injury: Biomarkers and Potential Therapeutic Targets
Degradomics is a proteomics sub-discipline whose goal is to identify and characterize protease-substrate repertoires. With the aim of deciphering and...
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Web-Based Resources to Investigate Protease Function
In 2001, the release of the first draft of the human genome marked the beginning of the Big Data era for biological sciences. Since then, the...
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Long noncoding RNAs underlie multiple domestication traits and leafhopper resistance in soybean
The origin and functionality of long noncoding RNA (lncRNA) remain poorly understood. Here, we show that multiple quantitative trait loci modulating...
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Regulatory Mechanism of Maize (Zea mays L.) miR164 in Salt Stress Response
AbstractSmall RNAs, especially microRNAs (miRNAs), play an essential role in the responses and adaptations of plants to many stresses, including salt...
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Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer
IntroductionPancreatic cancer is a highly aggressive cancer, and early diagnosis significantly improves patient prognosis due to the early...
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ncRNA-mediated overexpression of ubiquitin-specific proteinase 13 contributes to the progression of prostate cancer via modulating AR signaling, DNA damage repair and immune infiltration
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal form of prostate cancer, and the molecular mechanism driving mCRPC progression...
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Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration
The high heterogeneity of breast cancer (BC) caused by pathogenic gene mutations poses a challenge to immunotherapy, but the underlying mechanism...
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Identification of microRNAs and their Endonucleolytic Cleavaged target mRNAs in colorectal cancer
BackgroundColorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital...
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Development Immune-Related Prognostic Model and LncRNA-miRNA-mRNA ceRNA Network for Cervical Cancer
AbstractCervical cancer is a serious threat to women’s health. The aim of this study was to provide new insights into the mechanism of cervical...
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LncRNA Neat1/miR-298-5p/Srpk1 Contributes to Sevoflurane-Induced Neurotoxicity
Sevoflurane is a widely used volatile anesthetic, that can cause long-term neurotoxicity and learning and memory impairment. Long non-coding RNAs...
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MicroRNAs Regulating Autophagy in Neurodegeneration
Social and economic impacts of neurodegenerative diseases (NDs) become more prominent in our constantly aging population. Currently, due to the lack...
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Exploration of plant transcriptomes reveals five putative novel poleroviruses and an enamovirus
Transcriptome datasets available in public domain serve as valuable resource for identification and characterization of novel viral genomes....
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Roles of circRNAs in hematological malignancies
As one of the leading causes of death, hematologic malignancies are associated with an ever-increasing incidence, and drug resistance and relapse of...
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A high-fiber diet synergizes with Prevotella copri and exacerbates rheumatoid arthritis
Both preclinical and established rheumatoid arthritis (RA) patients display alterations in the gut microbiome. Prevotella spp. are preferentially...
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The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility
Pachytene PIWI-interacting RNAs (piRNAs), which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target...
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Characterization of DNA methylation as well as mico-RNA expression and screening of epigenetic markers in adipogenesis
This study aimed to use bioinformatics methods to characterize epigenetic changes in terms of micro-RNA(miRNA) expression and DNA methylation during...
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An overview of CCN4 (WISP1) role in human diseases
CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich matricellular protein is emerging as a key player in the...
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Exosome-Mediated Communication in Thyroid Cancer: Implications for Prognosis and Therapeutic Targets
Thyroid cancer (THCA) is one of the most common malignancies of the endocrine system. Exosomes have significant value in performing molecular...
