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Synergistic antidepressant-like effect of citicoline and CB 1 agonist in male mice
BackgroundThe endocannabinoid system plays a key role in the control of many emotional-correlated reactions such as stress, depressed mood, and...
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The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway
Vascular dementia (VD) is characterized with vascular cognitive impairment (VCI), which currently has few effective therapies in clinic. Neuronal...
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Citicoline and COVID-19: vis-à-vis conjectured
Coronavirus disease 2019 (COVID-19) is a current pandemic disease caused by a novel severe acute respiratory syndrome coronavirus virus respiratory...
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The Role of P2Y6 Receptors in the Mechanisms of the Neuroprotective Effect of Citicoline
Spontaneous bioelectrical activity of the brain and the duration of gas** were recorded in mice during modeling of global strangulation ischemia of...
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Nonlinear surface EMG analysis to detect the neuroprotective effect of citicoline in rat sciatic nerve crush injury
Surface electromyography (sEMG) is a method involving physiological signals with a complex behavior. The aim is to analyze the sEMG signals by...
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Effects of Citicoline on Structural/Functional Consequences of Focal Ischemia of the Rat Brain
Effects of citicoline on the volume of ischemically damaged cerebral tissue, dynamics of neurological deficiency, and indices of neurobehavioral...
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Citicoline Modulates Glaucomatous Neurodegeneration Through Intraocular Pressure-Independent Control
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss. Currently, intraocular pressure (IOP) is the only...
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Serum Levels of the Biomarkers Associated with Astrocytosis, Neurodegeneration, and Demyelination: Neurological Benefits of Citicoline Treatment of Patients with Ischemic Stroke and Atrial Fibrillation
Ischemic stroke is a main complication of atrial fibrillation (cardiac arrhythmia). The aim of our study was to estimate the effects of citicoline...
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Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a rare, adult-onset neurodegenerative movement disorder occurring in some carriers of a 55–200...
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Drug Synergism as the Basis of Rational Neuroprotection
Optimization of the choice of neuroprotective therapy regimens in patients with cerebrovascular diseases (CVD), taking into account the synergism of...
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Selection of Neuroprotective Therapy in Patients with Chronic Cerebral Ischemia Taking Account of the Synergism of Drug Interactions
Objective. To optimize selection of neuroprotective treatment protocols in patients with chronic cerebral ischemia taking account of synergism in...
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Studies of the Membrane-Protecting Potential of the Combination of 2-Ethyl-6-Methyl-Hydroxypyridine Succinate and Citicoline
Objectives. To assess changes in the phospholipid composition of blood plasma in patients with chronic cerebrovascular disease using the...
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Therapeutic management of ischemic stroke
Stroke is the third leading cause of years lost due to disability and the second-largest cause of mortality worldwide. Most occurrences of stroke are...
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Analysis of Fecal Microbiota in Patients with Hypertension Complicated with Ischemic Stroke
Ischemic stroke is a disease with a very high incidence in the clinic, and hypertension is the most important variable risk factor of ischemic...
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Molecular and Clinical Aspects of the Action of Cytidine Diphosphocholine on Cognitive Functions
Objectives. To systematize publications on drugs based on cytidine diphosphocholine (CDP-choline). Materials and methods. Systematic computer...
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An Understated Comorbidity: The Impact of Homelessness on Traumatic Brain Injury
Traumatic brain injury (TBI), a neurovascular injury caused by external force, is a common diagnosis among veterans and those experiencing...
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Genotoxicity of Psychotropic Drugs in Experimental and Clinical Studies
Data from studies of the genotoxic activity of psychotropic drugs published over the past 25 years were analyzed. Information describing the...
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Adjunctive cytoprotective therapies in acute ischemic stroke: a systematic review
With the introduction of endovascular thrombectomy (EVT), a new era for treatment of acute ischemic stroke (AIS) has arrived. However, despite the...
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Pharmacological Approaches in the Augmentation and Recovery of Brain Function
Pharmacological intervention for the augmentation of brain function in healthy individuals and for recovery after neurological conditions has reached...
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Impairments to Cognitive Control in Patients with Somatoform Disorders and Their Treatment
Objectives. To study impairments to cognitive control in patients with somatoform dysfunction of the autonomic nervous system (somatoform disorder –...