Search
Search Results
-
Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone
PurposeLung fibrosis is a heterogeneous lung condition characterized by excessive accumulation of scarred tissue, leading to lung architecture...
-
Beneficial action of cinnamic acid against ovarian cancer via network pharmacology analysis and the pharmacological activity assessment
Naturally occurring cinnamic acid (CA) shows the beneficial potential in the suppression of ovarian cancer (OC). Currently, the in-depth molecular...
-
Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis
PurposePancreatic β-cells protection is integral to insulin secretion in diabetic conditions. In this context, we investigated cinnamic acid in...
-
Rapid Colorimetric and Fluorometric Discrimination of Maleic Acid vs. Fumaric Acid and Detection of Maleic Acid in Food Additives
An anthracene thiazole based Schiff base L was synthesized and employed for fluorescence switch-on detection of maleic acid in aqueous DMSO. The...
-
Effect of Glycyrrhetic Acid Derivatives on Regulation of Thymocyte Volume
We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell...
-
Design, synthesis, and evaluation of novel cinnamic acid-tryptamine hybrid for inhibition of acetylcholinesterase and butyrylcholinesterase
BackgroundAcetylcholine deficiencies in hippocampus and cortex, aggregation of β-amyloid, and β-secretase over activity have been introduced as main...
-
Involvement of NLRP3 inflammasome pathway in the protective mechanisms of ferulic acid and p-coumaric acid in LPS-induced sickness behavior and neuroinflammation in mice
Ferulic acid (FA) and p-coumaric acid (PCA) are abundantly present in commonly consumed food and beverages. Being polyphenolic compounds, they have...
-
Evolution and Analysis of Caffeic Acid Transferase (COMT) in Seed Plants
Caffeic acid transferase ( COMT ) is a key enzyme in the lignin and melatonin synthesis pathways and plays an important role in plant growth and...
-
Integration of modern science into herbal medicine: application of pharmacokinetic-pharmacodynamic modeling in understanding nonclinical study of Cinnamomum cassia extract.
PurposeCKD-495 is a tablet form of Cinnamomum cassia Presl extract (CCE), which is a commonly used herb in traditional medicine that exhibits...
-
Effects of Sinapic Acid on Penicillin-Induced Epileptiform Activity in Rats
In our study, we investigated the effects of sinapic acid (SA), known for its antioxidant, antimicrobial, anti-inflammatory, and anticancer...
-
A comparative study of passive drug diffusion through human skin via intercellular and sweat duct route: effect of aging
A method of drug delivery that could provide control over medicine reaching the bloodstream for systemic circulation would be of immense importance....
-
Involvement of indoleamine 2, 3-dioxygenase (IDO) and brain-derived neurotrophic factor (BDNF) in the neuroprotective mechanisms of ferulic acid against depressive-like behaviour
Objective: Ferulic acid (FA) is a common food ingredient that is abundantly present in various routinely consumed food and beverages. Like many...
-
Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their...
-
A sensitive UPLC–ESI–MS/MS method for the quantification of cinnamic acid in vivo and in vitro: application to pharmacokinetic and protein binding study in human plasma
PurposeThe purpose of this study was to develop a sensitive method for quantifying cinnamic acid in human plasma using UPLC–ESI–MS/MS.
...
-
Ferulic acid attenuates pancreaticobiliary duct occlusion-induced inflammation in both pancreas and liver
IntroductionAcute pancreatitis is a systemic inflammatory disorder characterized by the hyperactivation of digestion enzymes and the release of...
-
Bee Propolis (Caffeic Acid Phenethyl Ester) Against Cancer
Caffeic acid phenethyl ester (CAPE) is the vital natural phenolic chemical composite present in a variety of plants which is also abundantly present...
-
Anticancer Role of Natural Phenolic Acids by Targeting Angiotensin-Converting Enzyme (ACE)
Recently, it has become obvious that renin-angiotensin system (RAS) plays an important role in cancer progression through angiotensin converting...
-
Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue
IntroductionUlcerative colitis is a chronic inflammation of the colon. However, the common treatment for it is accompanied by many complications....
-
Gut microbiota-derived 3-phenylpropionic acid promotes intestinal epithelial barrier function via AhR signaling
BackgroundThe intestinal epithelial barrier confers protection against the intestinal invasion by pathogens and exposure to food antigens and toxins....
-
Cinnamic Acid Protects the Nigrostriatum in a Mouse Model of Parkinson’s Disease via Peroxisome Proliferator-Activated Receptorα
Parkinson’s disease (PD) is the second most common devastating human neurodegenerative disorder and despite intense investigation, no effective...
