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Anticancer Role of Natural Phenolic Acids by Targeting Angiotensin-Converting Enzyme (ACE)

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The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 25))

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Abstract

Recently, it has become obvious that renin-angiotensin system (RAS) plays an important role in cancer progression through angiotensin converting enzyme (ACE), involving activation and upregulation of multiple oncogenic molecules. Accordingly, suppression of ACE and its subsequent downstream cascades has received considerable attention as a possible way to combat oncological diseases. In this book chapter, the role of a several plant-derived phenolic acids (Ellagic acid, Gallic acid, Caffeic acid) on inhibition of ACE is demonstrated, and involvement of this action in chemopreventive and chemotherapeutic properties of these natural compounds is discussed, with a special focus on antiangiogenic and antiinflammatory activities.

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Authors and Affiliations

  1. Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India

    Hardeep Singh Tuli & Anil Kumar Sharma

  2. Department of Cardiology, Advance Cardiac Centre, PGIMER, Chandigarh, 160012, India

    Kanupriya Vashishth

  3. NGO Praeventio, 50407, Tartu, Estonia

    Katrin Sak

  4. Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, 758002, India

    Ranjan K. Mohapatra

  5. Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, 243122, India

    Kuldeep Dhama

  6. Department of Chemistry, Maharishi Markandeshwar University, Sadopur, Haryana, 134007, India

    Manoj Kumar & Zahoor Abbas

  7. Department of Chemistry & Chemical Sciences, Central University of Himachal Pradesh, 176206, Dharamshala, India

    Kusham Lata

  8. Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Kayseri, 38039, Turkey

    Mukerrem Betul Yerer

  9. Department of Medical Lab Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali, Punjab, 140413, India

    Vivek Kumar Garg

  10. Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai, Maharashtra, 40056, India

    Ginpreet Kaur

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  1. Hardeep Singh Tuli
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  12. Ginpreet Kaur
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Correspondence to Hardeep Singh Tuli .

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  1. Institute of Cardiovascular Sciences, St. Boniface Hospital, Winnipeg, MB, Canada

    Sukhwinder K. Bhullar

  2. Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, MB, Canada

    Paramjit S. Tappia

  3. Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Tuli, H.S. et al. (2023). Anticancer Role of Natural Phenolic Acids by Targeting Angiotensin-Converting Enzyme (ACE). In: Bhullar, S.K., Tappia, P.S., Dhalla, N.S. (eds) The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases. Advances in Biochemistry in Health and Disease, vol 25. Springer, Cham. https://doi.org/10.1007/978-3-031-23621-1_23

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