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Centrosome, microtubule and DNA damage response
Centrosomes are the major microtubule-organizing center (MTOC), which are important cytoplasmic organelles regulating cell cycle, cell morphology,...
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Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies
Numerical and/or structural centrosome amplification (CA) is a hallmark of cancers that is often associated with the aberrant tumor karyotypes and...
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Centriolin interacts with HectD1 in a cell cycle dependent manner
ObjectiveThe centrosome is universally recognized as the microtubule organizing center of animal cells, but emerging evidence suggests that it has...
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Functional genetic variants in centrosome-related genes CEP72 and YWHAG confer susceptibility to gastric cancer
Structural and numeric centrosome aberrations can induce chromosome segregation errors and promote tumor development and progression. We...
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RAD6 inhibition enhances paclitaxel sensitivity of triple negative breast cancer cells by aggravating mitotic spindle damage
BackgroundPaclitaxel (PTX), a first-line therapy for triple negative breast cancers (TNBC) induces anti-tumor activity by microtubule stabilization...
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Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis
RationaleAdequate immunotherapies for anti-NMDAR encephalitis during pregnancy produce a relatively good clinical outcome for pregnant mothers and...
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CRISPR/Cas9 genome editing system confirms centriolin’s role in cytokinesis
ObjectiveIn addition to its function as the microtubule organizing center of the cell, the centrosome has functions in many other cellular processes...
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Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis
BackgroundThe maintenance of spindle pole integrity is essential for spindle assembly and chromosome segregation during mitosis. However, the...
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A novel HIF1α-STIL-FOXM1 axis regulates tumor metastasis
BackgroundMetastasis is the major cause of morbidity and mortality in cancer that involves in multiple steps including epithelial–mesenchymal...
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Clinical significance of TROAP in endometrial cancer and the antiproliferative and proapoptotic effects of TROAP knockdown in endometrial cancer cells: integrated utilization of bioinformatic analysis and in vitro test verification
Trophinin-associated protein (TROAP), a cytoplasmic protein essential for spindle assembly and centrosome integrity during mitosis, has been reported...
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Forcing dividing cancer cells to die; low‐dose drug combinations to prevent spindle pole clustering
Mitosis, under the control of the microtubule-based mitotic spindle, is an attractive target for anti-cancer treatments, as cancer cells undergo...
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Mutant p53 drives the loss of heterozygosity by the upregulation of Nek2 in breast cancer cells
BackgroundMutations in one allele of the TP53 gene in early stages are frequently followed by the loss of the remaining wild-type p53 (wtp53) allele...
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Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling
BackgroundWhole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal...
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Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions
Proper blood vessel formation requires coordinated changes in endothelial cell polarity and rearrangement of cell–cell junctions to form a functional...
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Par-4 in Cell Cycle Regulation
Cell cycle must be carefully controlled to ensure genetic materials are replicated once and only once per cycle and equal sister chromatid...
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The Golgi apparatus is the main microtubule-organizing center in differentiating skeletal muscle cells
Studies in differentiating skeletal muscle cells in vitro have revealed that the microtubule-organizing center shifts from the centrosome to the...
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Functions and dysfunctions of the mammalian centrosome in health, disorders, disease, and aging
Since its discovery well over 100 years ago (Flemming, in Sitzungsber Akad Wissensch Wien 71:81–147, 1875; Van Beneden, in Bull Acad R Belg 42:35–97,...
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Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation
During brain development, the nucleus of migrating neurons follows the centrosome and translocates into the leading process. Defects in these...
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Response of Therapy in Cell-Cycle Regulatory Genes in Breast Cancer
Dysregulation of the cell cycle, which permits for unrestricted cellular division, is a characteristic of cancer. Cells develop genetic changes that...
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The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo
The embryo of humans and other mammals requires the presence of two subcellular structures, named centrioles. The centrioles act as nucleation points...