Search
Search Results
-
Systematic comparison of transcriptomes of Caco-2 cells cultured under different cellular and physiological conditions
There is a need for standardized in vitro models emulating the functionalities of the human intestinal tract to study human intestinal health without...
-
Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells
Conjugated bile acids are synthesized in liver and subsequently secreted into the intestinal lumen from which they are actively reabsorbed and...
-
A human Caco-2-based co-culture model of the inflamed intestinal mucosa for particle toxicity studies
The intestinal barrier is a complex interface of the human body, possessing the largest contact surface to nutrients and antigens and containing a...
-
Analysis and optimization of a Caco-2 cell culture model for infection with human norovirus
Human noroviruses (hNoVs) are an important cause of acute gastroenteritis worldwide. However, the lack of a reproducible in vitro cell culture system...
-
Generation of Caco-2 cells stably expressing CYP3A4·POR·UGT1A1 and CYP3A4·POR·UGT1A1*6 using a PITCh system
The small intestine plays a critical role in the absorption and metabolism of orally administered drugs. Therefore, a model capable of evaluating...
-
Indigo enhances wound healing activity of Caco-2 cells via activation of the aryl hydrocarbon receptor
Indigo Naturalis, also known as Qing Dai (QD) is a compound obtained from Indigofera tinctoria, Isatis tinctoria, and Polygonum tinctoria and is...
-
Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay
Inflammatory bowel disease (IBD) is a widespread disease, affecting a growing demographic. The treatment of chronic inflammation located in the...
-
Bile salt–dependent lipase promotes the barrier integrity of Caco-2 cells by activating Wnt/β-catenin signaling via LRP6 receptor
AbstractBile salt–dependent lipase (BSDL) within intestinal lumen can be endocytosed by enterocytes and support the intestinal barrier function....
-
Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells
Human intestinal organoids (HIOs) are a promising in vitro model consisting of different intestinal cell types with a 3D microarchitecture resembling...
-
KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells
We studied the effect of KDM5 family demethylase inhibitors (JIB-04, PBIT, and KDOAM-25) on the penetration of SARS-CoV-2 pseudotyped viruses into...
-
3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Cetuximab, in combination with chemotherapy, is effective for...
-
Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines
BackgroundRelapse and metastasis in colorectal cancer (CRC) are often attributed to cancer stem-like cells (CSCs), as small sub-population of tumor...
-
Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations
BackgroundThe human Caco-2 cell line is a common in vitro model of the intestinal epithelial barrier. As the intestine is a major interface in...
-
Biological Application of a Fluorescent Zinc Sensing Probe for the Analysis of Zinc Bioavailability Using Caco-2 Cells as an In-Vitro Cellular Model
Zinc is essential for growth and development of all living organisms, especially human being. Deficiency of micronutrients like zinc and iron has...
-
Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2
BackgroundSeveral in silico studies have determined that quercetin, a plant flavonol, could bind with strong affinity and low free energy to...
-
Retraction Note: Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice
The Editors have retracted this article because the corresponding author raised concerns over the source of the data presented in this article, but...
-
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful blooms (CyanoHABs) pose a global ecological problem, and their lipopolysaccharides (LPS) are among the bioactive compounds...
-
Colorectal Cancer and Tumor Stromal Cells Have Different Effects on the Differentiation and Maturation of Dendritic Cells In Vitro
We compared the ability of SW837, SW480, HT-29, Caco-2, and HCT116 colorectal cancer lines and cancer-associated fibroblasts obtained from a...
-
Small silica nanoparticles transiently modulate the intestinal permeability by actin cytoskeleton disruption in both Caco-2 and Caco-2/HT29-MTX models
Amorphous silica nanoparticles are widely used as pharmaceutical excipients and food additive (E551). Despite the potential human health risks of...
